Quantitative MRI Evidence for Cognitive Reserve in Healthy Elders and Prodromal Alzheimer's Disease.
Quantitative MRI Evidence for Cognitive Reserve in Healthy Elders and Prodromal Alzheimer's Disease.
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DOI：
10.3233/jad-220197
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发表时间：
2022
影响因子：
4
通讯作者：
Hosseini, S. M. Hadi
中科院分区：
文献类型：
--
作者：
Fingerhut, Hannah;Gozdas, Elveda;Hosseini, S. M. Hadi
关键词：
认知储备（CR）被认为是阿尔茨海默病（AD）神经病理学和临床结果之间差异的原因之一。我们研究了教育-职业衍生的CR代理对遗忘型轻度认知障碍（aMCI）患者和健康老年人（HC）白质束生物学特性的影响。来自35名aMCI患者和28名HC患者的教育程度和职业复杂性评分（数据、人、物的复杂性）用于生成综合CR评分。定量磁共振成像（qMRI）和多壳扩散MRI用于提取主要白质束的大分子组织体积（MTV）。我们观察到，当年龄、性别、颅内容量和记忆能力保持不变时，aMCI与HC的CR和白质束MTV之间的关联存在显著差异。特别是，在aMCI中，较高的CR与左右背扣带、大胼胝体、右侧额枕下束和右侧上纵束（SLF）束的较差的束病理（较低的MTV）相关。相反，在HC中，较高的CR与较高的右侧海马旁扣带MTV和左侧SLF相关。我们的研究结果支持aMCI中的代偿性CR机制和HC中的神经保护机制，并提示CR在健康老年人与前驱AD患者白质大分子特性中的不同作用。
Cognitive reserve (CR) has been postulated to contribute to the variation observed between neuropathology and clinical outcomes in Alzheimer’s disease (AD). We investigated the effect of an education-occupation derived CR proxy on biological properties of white matter tracts in patients with amnestic mild cognitive impairment (aMCI) and healthy elders (HC). Educational attainment and occupational complexity ratings (complexity with data, people, and things) from thirty-five patients with aMCI and twenty-eight HC were used to generate composite CR scores. Quantitative magnetic resonance imaging (qMRI) and multi-shell diffusion MRI were used to extract macromolecular tissue volume (MTV) across major white matter tracts. We observed significant differences in the association between CR and white matter tract MTV in aMCI versus HC when age, gender, intracranial volume, and memory ability were held constant. Particularly, in aMCI, higher CR was associated with worse tract pathology (lower MTV) in the left and right dorsal cingulum, callosum forceps major, right inferior fronto-occipital fasciculus, and right superior longitudinal fasciculus (SLF) tracts. Conversely higher CR was associated with higher MTV in the right parahippocampal cingulum and left SLF in HC. Our results support compensatory CR mechanisms in aMCI and neuroprotective mechanisms in HC and suggest differential roles for CR on white matter macromolecular properties in healthy elders versus prodromal AD patients.