Coding sequence and alternative splicing of the mouse alpha 1(XI) collagen gene (Col11a1).
Coding sequence and alternative splicing of the mouse alpha 1(XI) collagen gene (Col11a1).
复制标题
小鼠 α 1(XI) 胶原蛋白基因 (Col11a1) 的编码序列和选择性剪接。
DOI：
10.1006/geno.1995.1151
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Ramirez,F
中科院分区：
文献类型：
--
作者：
Yoshioka,H;Inoguchi,K;Khaleduzzaman,M;Ninomiya,Y;Andrikopoulos,K;Ramirez,F
分离了与小鼠α1（XI）胶原基因（Col11a1）的整个编码序列相对应的几个重叠cDNA克隆。概念氨基酸翻译表明与人α1（XI）链具有高度序列同一性（93%）。克隆实验还揭示了编码α1（XI）氨基球状结构域酸性区域内85个残基的序列的选择性剪接。对来自不同胚胎组织的RNA样本的分析表明，选择性剪接可能仅限于注定成为骨骼的组织。
Several overlapping cDNA clones corresponding to the entire coding sequence of the mouse α1(XI) collagen gene (Col11a1) were isolated. The conceptual amino acid translation indicated a high degree of sequence identity (93%) with the human α1(XI) chain. The cloning experiments also revealed alternative splicing of the sequence coding for 85 residues located within the acidic region of the amino-globular domain of α1(XI). Analysis of RNA samples from different embryonic tissues suggested that alternative splicing might be confined to tissue destined to become bone.