Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression.
Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression.
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DOI：
10.1016/j.it.2008.05.002
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发表时间：
2008-08
影响因子：
16.8
通讯作者：
Hong JS
中科院分区：
文献类型：
--
作者：
Gao HM;Hong JS
神经退行性疾病是一组慢性进行性疾病，其特征是中枢神经系统(CNS)离散区域的神经元逐渐丧失。其渐进性的机制(S)尚不清楚，但及时和良好控制的炎症反应对于中枢神经系统的完整性和正常功能是必不可少的。大量证据表明，在各种神经退行性疾病中存在一种常见的炎症机制。我们假设，在患病的中枢神经系统中，受损神经元和调节失调、过度激活的小胶质细胞之间的相互作用会产生一个恶性的自我传播循环，导致不受控制的长期炎症，从而推动神经退行性疾病的慢性进展。我们进一步提出，通过中断恶性循环来动态调节这种炎症反应可能成为神经退行性疾病的一种疾病修正治疗策略。
Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in discrete areas of the central nervous system (CNS). The mechanism(s) underlying their progressive nature remains unknown but a timely and well-controlled inflammatory reaction is essential for the integrity and proper function of the CNS. Substantial evidence has documented a common inflammatory mechanism in various neurodegenerative diseases. We hypothesize that in the diseased CNS, interactions between damaged neurons and dysregulated, overactivated microglia create a vicious self-propagating cycle causing uncontrolled, prolonged inflammation that drives the chronic progression of neurodegenerative diseases. We further propose that dynamic modulation of this inflammatory reaction by interrupting the vicious cycle might become a disease-modifying therapeutic strategy for neurodegenerative diseases.