Autoantibodies to tyrosinase
Autoantibodies to tyrosinase
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酪氨酸酶自身抗体
作者：
P. Fishman;O. Merimski;E. Baharav;Y. Shoenfeld
酪氨酸酶是一种在正常黑色素细胞和黑色素瘤细胞中参与黑色素生成过程的酶。酶被认为是各种自身免疫性疾病的自身抗原；因此，在白癜风和黑色素瘤患者中检测到抗酪氨酸酶抗体后，酪氨酸酶被定义为这些情况下的自身抗原。在一些黑色素瘤患者中，这种疾病与皮肤上出现“白癜风样”的白色斑块有关，称为黑色素瘤相关性色素减退（MAH）。在这篇文章中，作者总结了最近与抗酪氨酸酶抗体相关的数据，并扩展了它们在白癜风、黑色素瘤和MAH发病机制中的作用。此外，还介绍了抗酪氨酸酶抗体的有益临床应用。
Tyrosinase is an enzyme that participates in the process of melanin production in normal melanocytes and melanoma cells. Enzymes are known to be autoantigens in various autoimmune disorders; thus, after the detection of antityrosinase antibodies in patients with vitiligo and melanoma, tyrosinase was defined as an autoantigen in these conditions. In some patients with melanoma the disease is associated with the appearance of "vitiligo‐like" white patches on the skin, called melanoma‐associated hypopigmentation (MAH). In this article, the authors summarize the recent data related to antityrosinase antibodies and expand on their role in the pathogenesis of vitiligo, melanoma, and MAH. In addition, the beneficial clinical applications of antityrosinase antibodies are presented.
DOI：
10.1073/pnas.89.2.466
发表时间：
1992-01-15
影响因子：
11.1
作者：
MITTELMAN, A;CHEN, ZJ;FERRONE, S
通讯作者：
FERRONE, S
影响因子：
15.9
作者：
MITTELMAN, A;CHEN, ZJ;FERRONE, S
通讯作者：
FERRONE, S