FACTORS AFFECTING LYMPHOID-CELLS IN SMALL INTESTINAL EPITHELIUM OF MOUSE
FACTORS AFFECTING LYMPHOID-CELLS IN SMALL INTESTINAL EPITHELIUM OF MOUSE
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DOI：
10.1159/000231071
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发表时间：
1973-01-01
期刊：
影响因子：
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通讯作者：
GLAISTER, JR
中科院分区：
文献类型：
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作者：
GLAISTER, JR
研究了常规和无菌小鼠淋巴细胞的个体发育。两组在4周龄之前的发育情况相似。在新生儿生命的前2周，细胞很少，但在2至4周龄之间数量迅速增加。在常规小鼠中，细胞数量继续增加，但在无菌小鼠中保持不变。将成年无菌小鼠暴露于常规环境导致上皮淋巴细胞群体的大小增加到常规小鼠的特征。饲养常规的断奶小鼠经杀虫剂处理的饮用水不能防止断奶后淋巴细胞数量的增加。这些结果被解释为表明肠上皮中的淋巴样细胞群是第二级或外周淋巴组织的一部分，而不是第一级系统（如胸腺和法氏囊）的一部分。
The ontogeny of the lymphoid cells in conventional and germ-free mice has been studied. Development is similar in both groups up to the age of 4 weeks. During the first 2 weeks of neonatal life, few cells are present, but the numbers increase rapidly between 2 and 4 weeks of age. The number of cells continues to increase in conventional mice, but remains static in germ-free mice. Exposing adult germ-free mice to a conventional environment results in an increase in the size of the epithelial lymphocyte population to that characteristic of conventional mice. Rearing conventional weanling mice on antibiotic-treated drinking water does not prevent the post-weaning increase in lymphoid cell numbers. The results are interpreted as showing that the lymphoid cell population in the intestinal epithelium is part of the second-level or peripheral lymphoid tissue rather than part of the first-level systems such as the thymus and bursa of Fabricius.