A context dependent role for Wnt signaling in tumorigenesis and stem cells
A context dependent role for Wnt signaling in tumorigenesis and stem cells
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DOI：
10.4161/cc.7.6.5569
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发表时间：
2008-03-15
期刊：
影响因子：
4.3
通讯作者：
Cardo, Carlos Cordon
中科院分区：
文献类型：
--
作者：
Matushansky, Igor;Maki, Robert G.;Cardo, Carlos Cordon
Wnt信号转导通路协调多种活动，从发育、分化到增殖和肿瘤发生。也许最值得注意的是，Wnt信号能够以细胞特异性和分化阶段依赖的方式完成这一系列不同的活动。在这篇综述中，我们将强调Wnt信号在三种类型的组织干细胞及其相应的恶性肿瘤中的不同作用。
The Wnt signal transduction pathway coordinates myriad activities, from development and differentiation to proliferation and tumorigenesis. What is perhaps most remarkable is that Wnt signaling is able to accomplish this diverse set of activities in a cell-specific and differentiation stage-dependent manner. In this review, we will highlight the diverse effect of Wnt signaling on three types of tissue stem cells and their corresponding malignancies.