Multi-functional NaErF4:Yb nanorods: enhanced red upconversion emission, in vitro cell, in vivo X-ray, and T2-weighted magnetic resonance imaging.
Multi-functional NaErF4:Yb nanorods: enhanced red upconversion emission, in vitro cell, in vivo X-ray, and T2-weighted magnetic resonance imaging.
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DOI：
10.1039/c3nr05782h
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发表时间：
2014-02
期刊：
影响因子：
6.7
通讯作者：
Haibo Wang;W. Lu;Tianmei Zeng;Zhigao Yi;L. Rao;Hongrong Liu;S. Zeng
中科院分区：
文献类型：
--
作者：
Haibo Wang;W. Lu;Tianmei Zeng;Zhigao Yi;L. Rao;Hongrong Liu;S. Zeng
本文采用水热法合成了多功能六方相NaErF 4：Yb纳米棒。Yb（3+）掺杂可以提高多功能NaErF 4纳米棒的上转换发光强度和红绿色比。更重要的是，由于Er和Yb的距离减小，可以获得显著增强的红色UCL，这不同于通常的Yb/Er掺杂的NaYF 4基质的绿色UCL。当Yb（3+）掺杂浓度达到30%时，UCL的强度最强。体外细胞成像和HeLa细胞的局部UCL光谱显示，这些NaErF 4：30%Yb（3+）纳米棒是理想的纳米探针，没有自发荧光的光学生物成像。此外，这些纳米棒具有大的X射线吸收离子（Er（3+）和掺杂Yb（3+）），并首次成功地用作体内X射线生物成像的造影剂。除了优异的UCL和X射线吸收特性外，这些纳米棒还具有显著的顺磁性，可用作T2加权磁共振成像（MRI）试剂。因此，这些增强的红色UCL NaErF 4纳米晶体具有优异的顺磁性能和X射线吸收性能，可以用作光学生物成像，MRI，计算机X射线断层扫描（CT）的有前途的多模态纳米探针，并可能在生物分离中具有潜在的应用。
In this paper, multi-functional hexagonal phase NaErF4:Yb nanorods were synthesized by a facile hydrothermal method. The upconversion luminescence (UCL) intensity and red to green ratio of the multi-functional NaErF4 nanorods can be improved by Yb(3+) doping. More importantly, owing to the decreased distance of Er and Yb, the significant enhancement of red UCL can be obtained, which is different to the usual green UCL of Yb/Er doped NaYF4 host. In addition, the intensity of UCL is strongest when the Yb(3+)-doped concentration reached 30%. The in vitro cell imaging and localized UCL spectra taken from HeLa cells revealed that these NaErF4: 30% Yb(3+) nanorods are ideal nanoprobes with absence of autofluorescence for optical bioimaging. Moreover, these nanorods possess large X-ray absorption ions (Er(3+) and doped Yb(3+)), and were successfully used as contrast agents for in vivo X-ray bioimaging for the first time. In addition to the excellent UCL and X-ray absorption properties, these nanorods present significant paramagnetic properties and can be used as T2-weighted magnetic resonance imaging (MRI) agents. Therefore, these enhanced red UCL NaErF4 nanocrystals with excellent paramagnetic properties and X-ray absorption properties can be used as promising multi-modal nanoprobes for optical bioimaging, MRI, computed X-ray tomography (CT), and may have potential applications in bioseparation.