ANTI-ALDOSTERONERGIC EFFECT OF TORASEMIDE
ANTI-ALDOSTERONERGIC EFFECT OF TORASEMIDE
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DOI：
10.1016/0014-2999(91)90812-5
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发表时间：
1991-11-26
影响因子：
5
通讯作者：
WATANABE, M
中科院分区：
文献类型：
--
作者：
UCHIDA, T;YAMANAGA, K;WATANABE, M
在正常血压大鼠和醋酸脱氧皮质酮（DOCA） - 盐水负荷高血压大鼠中研究了托拉塞米和呋塞米的利尿作用。托拉塞米（0.3 - 3毫克/千克）和呋塞米（3 - 30毫克/千克）在正常血压大鼠中具有剂量依赖性的显著利尿作用。仅在托拉塞米的情况下观察到钾潴留。托拉塞米在DOCA - 盐水负荷高血压大鼠中也具有剂量依赖性的显著利尿作用，而呋塞米则没有。较高剂量的托拉塞米（10毫克/千克）和呋塞米（100毫克/千克）以相似的方式增加正常血压大鼠的血浆肾素活性和醛固酮浓度。通过测定体内醛固酮受体结合来测试托拉塞米可能的抗醛固酮作用。托拉塞米以剂量依赖性方式抑制醛固酮与其在大鼠肾细胞质部分的受体结合，而呋塞米则无此作用。这些结果有力地表明托拉塞米的抗醛固酮作用有助于减少尿钾排泄。
The diuretic actions of torasemide and furosemide were studied in normotensive rats and in deoxycorticosterone acetate (DOCA)-saline-loaded hypertensive rats. Torasemide (0.3 approximately 3 mg/kg) and furosemide (3 approximately 30 mg/kg) had a dose-dependent and significant diuretic action in normotensive rats. Potassium retention was only observed in the case of torasemide. Torasemide also had a dose-dependent and significant diuretic action in DOCA-saline-loaded hypertensive rats, whereas furosemide did not. Higher doses of torasemide (10 mg/kg) and furosemide (100 mg/kg) increased both plasma renin activity and aldosterone concentration in normotensive rats in a similar manner. In vivo aldosterone receptor binding was determined to test the possible anti-aldosteronergic effect of torasemide. Torasemide inhibited the binding of aldosterone to its receptor in the cytoplasmic fraction of rat kidney in a dose-dependent manner, while furosemide produced no effect. These results suggest strongly that an anti-aldosteronergic action of torasemide contributes to producing less kaliuresis.