Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons
Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons
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DOI：
10.1073/pnas.1106862108
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发表时间：
2011-09-13
影响因子：
11.1
通讯作者：
Min, Kyung-Tai
中科院分区：
文献类型：
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作者：
Chang, Karen T.;Niescier, Robert F.;Min, Kyung-Tai
线粒体的适当分布对神经元尤其重要，因为它们的极化结构和高能量需求。轴突中的线粒体不断地响应生理需要而运动，但调节线粒体运动的信号还不是很清楚。除了产生ATP外，缓冲钙离子是线粒体的另一项主要功能。线粒体中许多酶的活性也是依赖于钙的，这表明线粒体内的钙浓度对线粒体的功能是重要的。在此，我们报道了轴突中线粒体的运动受到线粒体基质钙离子的主动调节。线粒体Ca~(2+)单转运体通过Ca~(2+)内流调节线粒体转运，线粒体Ca~(2+)含量与线粒体运动速度呈负相关。此外，Miro1蛋白在线粒体对钙的吸收中发挥作用，从而影响线粒体的运动。
The proper distribution of mitochondria is particularly vital for neurons because of their polarized structure and high energy demand. Mitochondria in axons constantly move in response to physiological needs, but signals that regulate mitochondrial movement are not well understood. Aside from producing ATP, Ca2+ buffering is another main function of mitochondria. Activities of many enzymes in mitochondria are also Ca2+-dependent, suggesting that intramitochondrial Ca2+ concentration is important for mitochondrial functions. Here, we report that mitochondrial motility in axons is actively regulated by mitochondrial matrix Ca2+. Ca2+ entry through the mitochondrial Ca2+ uniporter modulates mitochondrial transport, and mitochondrial Ca2+ content correlates inversely with the speed of mitochondrial movement. Furthermore, the miro1 protein plays a role in Ca2+ uptake into the mitochondria, which subsequently affects mitochondrial movement.