High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells
High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells
复制标题
DOI：
10.1016/s0966-3274(03)00058-3
复制
发表时间：
2003-07-01
影响因子：
1.5
通讯作者：
Suciu-Foca, N
中科院分区：
文献类型：
--
作者：
Manavalan, JS;Rossi, PC;Suciu-Foca, N
抗原特异性CD8(+) CD28(-) T抑制细胞（T-s）与树突状细胞（DC）之间的直接相互作用通过诱导免疫球蛋白样转录物3 （ILT3）和ILT4的上调而导致DC的耐受。我们在这里表明，这种耐受性DC使同种异体反应性CD4(+) CD45RO(+) CD25(+) T细胞失能，将它们转化为调节性T细胞（T- r）， T- r反过来通过耐受其他DC继续级联抑制。白细胞介素10 （IL-10）和干扰素α (ifn - α)也诱导DC中ILT3和ILT4上调，使其产生耐受性。这意味着dc介导的抑制有一个共同的机制。这一发现以及在同种异体器官移植受者中观察到的静止与供体特异性T和T循环中的存在有关，强调了耐受性DC和T细胞之间的串话在抑制免疫反应中的重要性。(C) 2003 Elsevier B.V.版权所有
The direct interaction between antigen specific CD8(+) CD28(-) T suppressor cells (T-s) with dendritic cells (DC) results in the tolerization of DC by inducing the upregulation of immunologlobulin like transcript 3 (ILT3) and ILT4. We show here that such tolerogenic DC anergize alloreactive CD4(+) CD45RO(+) CD25(+) T cells converting them into regulatory T cells (T-R), which in turn, continue the cascade of suppression by tolerizing other DC. Interleukin 10 (IL-10) and interferon-alpha (IFN-alpha) also induce ILT3 and ILT4 upregulation in DC, rendering them tolerogenic. This implies a common mechanism of DC-mediated suppression. This finding and the observation that in organ allograft recipients quiescence is associated with the presence in the circulation of donor-specific T, and T, emphasize the importance of the cross talk between tolerogenic DC and T cells in suppression of the immune response. (C) 2003 Elsevier B.V. All rights reserved.