Antioxidant systems in tumour cells: the levels of antioxidant enzymes, ferritin, and total iron in a human hepatoma cell line.
Antioxidant systems in tumour cells: the levels of antioxidant enzymes, ferritin, and total iron in a human hepatoma cell line.
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DOI：
10.3109/10715768609051640
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发表时间：
1986-01-01
期刊：
影响因子：
--
通讯作者：
Bannister, J V
中科院分区：
文献类型：
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作者：
Bannister, W H;Federici, G;Bannister, J V
具有B型肝炎病毒基因组的人肝癌细胞系Hep 3B显示铜/锌超氧化物歧化酶活性降低超过80%，锰超氧化物歧化酶活性降低超过90%，过氧化氢酶活性降低超过70%，谷胱甘肽过氧化物酶和谷胱甘肽S-转移酶活性缺乏，与正常尸检肝脏相比，铁蛋白含量增加超过270倍，总铁增加25倍。这些低抗氧化酶活性和铁超负荷的条件是那些支持氧自由基和DNA损伤的积累，通常被认为是致癌机制。
The human hepatoma cell line Hep 3B, which has the hepatitis B virus genome, shows over 80% decrease of copper/zinc superoxide dismutase activity, over 90% decrease of manganese superoxide dismutase activity, over 70% decrease of catalase activity, absence of glutathione peroxidase and glutathione S-transferase activities, over 270-fold increase of ferritin content and 25-fold increase of total iron compared to normal autopsy liver. These conditions of low antioxidant enzyme activities and iron overload are those which support the accumulation of oxygen free-radicals and DNA damage commonly considered to be carcinogenic mechanisms.