Effect of blood flow, tumour and cold stress in a female breast: a novel time-accurate computer simulation
Effect of blood flow, tumour and cold stress in a female breast: a novel time-accurate computer simulation
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DOI：
10.1243/0954411011535975
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发表时间：
2001-01-01
期刊：
影响因子：
1.8
通讯作者：
Sudharsan, NM
中科院分区：
文献类型：
--
作者：
Ng, EYK;Sudharsan, NM
乳腺癌是妇女的一种可怕的疾病，早期发现有助于治愈。乳房X光检查是目前检测乳房异常的标准工具，但对于致密乳房的女性，其灵敏度较低。已经发现，具有异常热像图的妇女处于较高的风险中，并且具有较差的预后。然而，执行和解释热谱图需要细致的培训。计算机模拟可以是一个额外的工具，以帮助临床医生在解释。在本文中。，开发了一种新颖且灵活的女性乳房有限元模型。稳态和时间依赖的解决方案，获得。稳态解全局匹配实验热成像结果与适当选择的血液灌注源项，组织厚度和几何缩放因子。尽管模拟可能在提供唯一解决方案（即，由于肿瘤与乳房表面温度之间的复杂生理关系，肿瘤的精确大小和位置）方面没有用，但它仍然有助于“消除分析”。这种类型的分析的一个例子。
Breast cancer is a dreadful disease among women and early detection helps in achieving a cure. The mammogram is presently the standard tool for detecting breast abnormality, but its sensitivity is lower for women with dense breasts. It has been found that women with an abnormal thermogram are at a higher risk and have a poorer prognosis. However, performing and interpreting thermograms requires meticulous training. Computer simulations can be an additional tool to help the clinician in the interpretation. In this paper., a novel and flexible finite element model of a female breast is developed. Both steady state and time-dependent solutions are obtained. Steady state solutions globally match experimental thermographic results with the proper choice of blood perfusion source terms, tissue thickness and geometric scaling factor. Although the simulations may not be useful in providing a unique solution (i.e. exact size and location of the tumour owing to the complex physiological relationship between the tumour and the breast surface temperature), it would nevertheless help in the 'analysis by elimination. An example of this type of analysis is also presented.