Impact of weight loss, appetite, and the inflammatory response on quality of life in gastrointestinal cancer patients
Impact of weight loss, appetite, and the inflammatory response on quality of life in gastrointestinal cancer patients
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DOI：
10.1080/01635589809514722
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发表时间：
1998-01-01
影响因子：
2.9
通讯作者：
McArdle, CS
中科院分区：
文献类型：
--
作者：
O'Gorman, P;McMillan, DC;McArdle, CS
研究了晚期胃肠道癌患者体重减轻、食欲、炎症反应和生活质量之间的关系。测量了119例患者的身高、体重和皮褶厚度。取血分析C-反应蛋白和白蛋白。使用EuroQol EQ-5D和EORTC QLQ-C30问卷评估食欲、体能状态和生活质量。97名患者的体重减轻>患病前体重的5%（中位数17.1%）;其余22名患者体重稳定。与体重稳定组相比，体重下降组的人体测量值和循环白蛋白浓度显著降低（p < 0.01），循环C反应蛋白浓度显著升高（p < 0.001）。减肥组的食欲评分、体能状态、EuroQol EQ-5D和EORTC QLQ-C30评分也较低（p < 0.01）。当减肥癌症患者根据他们是否有明显的炎症反应进行分组时，白蛋白浓度、食欲和Karnofsky体力状态在有明显炎症反应的组中显著较低（p < 0.05）。本研究的结果与体重减轻、食欲下降和炎症反应升高是降低胃肠道癌症患者生活质量的重要相关因素一致。
The relationship between weight loss, appetite, the inflammatory response, and quality of life in patients with advanced gastrointestinal cancer was examined. Height weight, and skinfold anthropometry were measured in 119 patients. Blood was taken for analysis of C-reactive protein and albumin. Appetite, performance status, and quality of life were assessed using EuroQol EQ-5D and EORTC QLQ-C30 questionnaires. Weight loss was >5% (median 17.1%) of their preillness weight in 97 patients; the remaining 22 patients were weight stable. Anthropometric measurements and circulating albumin concentrations were significantly lower (p < 0.01) and circulating concentrations of C-reactive protein were significantly higher in the weight-losing than in the weight-stable group (p < 0.001). Appetite scores, performance status, and EuroQol EQ-5D and EORTC QLQ-C30 scores were also lower in the weight-losing group (p < 0.01). When the weight-losing cancer patients were divided on the basis of whether they had a marked inflammatory response, albumin concentrations appetite, and Karnofsky performance status were significantly lower (p < 0.05) in the group with a marked inflammatory response. The results of the present study are consistent with weight loss, reduction of appetite, and an elevated inflammatory response being important related factors in lowering the quality of life of gastrointestinal cancer patients.