High-fat diet during pregnancy lowers fetal weight and has a long-lasting adverse effect on brown adipose tissue in the offspring
High-fat diet during pregnancy lowers fetal weight and has a long-lasting adverse effect on brown adipose tissue in the offspring
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怀孕期间的高脂肪饮食会降低胎儿的体重，并对后代的棕色脂肪组织产生长期的不良影响
DOI：
10.1017/s2040174422000551
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发表时间：
2022-10
影响因子：
1.7
通讯作者：
Mihoko Yamaguchi;Jun Mori;Nozomi Nishida;Satoshi Miyagaki;Y. Kawabe;T. Ota;Hidechika Morimoto;Yusuke Tsuma;S. Fukuhara;T. Ogata;Takuro Okamaura;Naoko Nakanishi;M. Hamaguchi;Hisakazu Nakajima;M. Fukui;T. Iehara
中科院分区：
文献类型：
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作者：
Mihoko Yamaguchi;Jun Mori;Nozomi Nishida;Satoshi Miyagaki;Y. Kawabe;T. Ota;Hidechika Morimoto;Yusuke Tsuma;S. Fukuhara;T. Ogata;Takuro Okamaura;Naoko Nakanishi;M. Hamaguchi;Hisakazu Nakajima;M. Fukui;T. Iehara
摘要 妊娠期和哺乳期母亲肥胖和营养不良已被认为会增加后代一生中肥胖和代谢紊乱的风险。然而，营养不良产生决定性影响的妊娠期尚不清楚。棕色脂肪组织（BAT）由于其氧化葡萄糖和脂肪酸的效率高，在能量代谢中发挥着关键作用。本研究旨在确定母亲仅在怀孕期间摄入高脂肪饮食 (HFD) 对子代小鼠 BAT 和能量代谢的影响。从胚胎第 2.5 天开始，母鼠就被喂食 HFD 或正常饲料。怀孕期间摄入 HFD 会导致母鼠出现葡萄糖不耐受和高血压。在 HFD 喂养的母鼠的后代中，母体 HFD 降低了胎儿体重，但不影响胎盘重量，而出生后摄入 HFD 则加剧了 12 月龄时的耗氧量和寒冷诱导的生热作用，同时 BAT 中的脂滴大小增加。这些数据表明，仅在怀孕期间食用 HFD 会对 BAT 产生长期影响。总的来说，这些发现表明孕期营养对于后代能量代谢的重要性，因此孕妇应保证孕期适当营养，以保证后代正常的能量代谢。
Abstract Maternal obesity and malnutrition during gestation and lactation have been recognized to increase the risk of obesity and metabolic disorders in the offspring across their lifespan. However, the gestational period during which malnutrition exerts a decisive effect is unclear. Brown adipose tissue (BAT) plays a critical role in energy metabolism owing to its high efficiency in oxidizing glucose and fatty acids. This study aimed to determine the impact of maternal high-fat diet (HFD) consumption only during pregnancy on BAT and energy metabolism in offspring mice. Dams were fed an HFD or a normal chow diet from embryonic day 2.5. HFD consumption during pregnancy induced glucose intolerance and hypertension in dams. In the offspring of HFD-fed dams, maternal HFD lowered fetal weight without affecting placental weight, whereas HFD consumption after birth exacerbated oxygen consumption and cold-induced thermogenesis at 12 months of age, accompanied by increased lipid droplet size in BAT. These data demonstrate that HFD consumption only during pregnancy exerts a long-lasting effect on BAT. Collectively, these findings indicate the importance of nutrition during pregnancy with respect to the energy metabolism of the offspring, and pregnant women should thus ensure proper nutrition during pregnancy to ensure normal energy metabolism in the offspring.