Observing conversational laughter in frontotemporal dementia.
Observing conversational laughter in frontotemporal dementia.
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观察额颞叶痴呆患者的对话笑声。
DOI：
10.1136/jnnp-2016-314931
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Levenson,RobertW
中科院分区：
文献类型：
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作者：
Pressman,PeterS;Simpson,Michaela;Gola,Kelly;Shdo,SuzanneM;Spinelli,EdoardoG;Miller,BruceL;Gorno-Tempini,MariaLuisa;Rankin,Katherine;Levenson,RobertW
背景我们进行了一项观察性研究，在痴呆患者和家庭照顾者之间的谈话中，笑声。患者被诊断为（1）行为变异型额颞叶痴呆（bvFTD），（2）右颞叶变异型额颞叶痴呆（rtFTD），（3）原发性进行性失语症的语义变异型（svPPA），（4）非流利变异型原发性进行性失语症（nfvPPA）或（5）早发性阿尔茨海默病（eoAD）。我们假设bvFTD患者对自己的讲话的反应比其他痴呆组或对照组少，而rtFTD患者无论谁在讲话都笑得少。记录eoAD（n=17）和健康对照（n=156）（视频和音频），同时讨论他们与健康对照同伴的关系中的问题。仅使用音轨，笑了识别训练有素的编码器，然后进一步分类的自动化算法发生在参与者自己的发声（“自我”上下文）或期间或不久后，合作伙伴的发声（“合作伙伴”上下文）。ResultsIndividuals与bvFTD，eoAD或rtFTD笑了自己和合作伙伴比其他组的上下文中少。与健康对照组相比，bvFTD患者的笑声相对于他们自己的言语更少。那些与nfvPPA笑了更多的合作伙伴背景下相比，健康controls.ConclusionsLaughter在回应自己的发声或那些对话的合作伙伴可能是一个临床上有用的措施，在痴呆症的诊断。
BackgroundWe performed an observational study of laughter during seminaturalistic conversations between patients with dementia and familial caregivers. Patients were diagnosed with (1) behavioural variant frontotemporal dementia (bvFTD), (2) right temporal variant frontotemporal dementia (rtFTD), (3) semantic variant of primary progressive aphasia (svPPA), (4) non-fluent variant primary progressive aphasia (nfvPPA) or (5) early onset Alzheimer’s disease (eoAD). We hypothesised that those with bvFTD would laugh less in response to their own speech than other dementia groups or controls, while those with rtFTD would laugh less regardless of who was speaking.MethodsPatients with bvFTD (n=39), svPPA (n=19), rtFTD (n=14), nfvPPA (n=16), eoAD (n=17) and healthy controls (n=156) were recorded (video and audio) while discussing a problem in their relationship with a healthy control companion. Using the audio track only, laughs were identified by trained coders and then further classed by an automated algorithm as occurring during or shortly after the participant’s own vocalisation ('self' context) or during or shortly after the partner’s vocalisation ('partner' context).ResultsIndividuals with bvFTD, eoAD or rtFTD laughed less across both contexts of self and partner than the other groups. Those with bvFTD laughed less relative to their own speech comparedwith healthy controls. Those with nfvPPA laughed more in the partner context compared with healthy controls.ConclusionsLaughter in response to one’s own vocalisations or those of a conversational partner may be a clinically useful measure in dementia diagnosis.