Caffeine prevents age-associated recognition memory decline and changes brain-derived neurotrophic factor and tirosine kinase receptor (TrkB) content in mice
Caffeine prevents age-associated recognition memory decline and changes brain-derived neurotrophic factor and tirosine kinase receptor (TrkB) content in mice
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DOI：
10.1016/j.neuroscience.2008.03.038
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发表时间：
2008-06-02
期刊：
影响因子：
3.3
通讯作者：
Porciuncula, L. O.
中科院分区：
文献类型：
--
作者：
Costa, M. S.;Botton, P. H.;Porciuncula, L. O.
咖啡因对人类认知的有益影响在人类中是有争议的，而它对啮齿动物的好处已经被很好地描述出来了。然而，大多数研究都是在急性服用咖啡因的情况下进行的，用于评估认知的任务含有令人厌恶的成分。在这里，我们通过物体识别任务(ORT)以及对海马区脑源性神经营养因子(BNDF)和酪氨酸激酶受体(TrkB)免疫含量的影响，评估了直到老年的咖啡因对小鼠识别记忆的影响。成年小鼠(6个月大)在12个月期间饮用饮用水或咖啡因(1 mg/mL)。在18个月大的时候，两组都接受了ORT测试。我们的结果表明，与成年(6月龄)相比，老年小鼠的再认记忆表现出较差的表现。此外，咖啡因治疗的小鼠在ORT中表现出与成年小鼠相似的表现，而与年龄匹配的对照组小鼠相比有所改善。咖啡因还抵消了与年龄相关的BDNF和TrkB免疫含量的增加。我们的结果与其他研究结果相印证，并强化了成年时摄入咖啡因可能会防止认知记忆随着年龄的增长而衰退。这种预防作用可能与降低海马区BDNF和TrkB免疫含量有关。(C)2008年IBRO。爱思唯尔有限公司出版。保留所有权利。
The beneficial effects of caffeine on cognition are controversial in humans, whereas its benefit in rodents had been well characterized. However, most studies were performed with acute administration of caffeine and the tasks used to evaluate cognition had aversive components. Here, we evaluated adulthood administration of caffeine up to old age on recognition memory in mice using the object recognition task (ORT) and on brain-derived neurotrophic factor (BNDF) and tirosine kinase receptor (TrkB) immunocontent in the hippocampus. Adult mice (6 months old) received either drinking water or caffeine (1 mg/mL) during 12 months. At 18 months of age both groups were tested for ORT. Our results showed that aged mice exhibited lower performance in the recognition memory compared with adults (6 months old). Furthermore, caffeine-treated mice showed similar performance to adult mice in the ORT and an improvement compared with their age-matched control mice. Caffeine also counteracted the age-related increase in BDNF and TrkB immunocontent. Our results corroborate with other studies and reinforce that caffeine consumed in adulthood may prevent recognition memory decline with aging. This preventive effect may involve a decrease in the hippocampal BDNF and TrkB immunocontent. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.