Dissociable contributions of the mid-ventrolateral frontal cortex and the medial temporal lobe system to human memory
Dissociable contributions of the mid-ventrolateral frontal cortex and the medial temporal lobe system to human memory
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DOI：
10.1016/j.neuroimage.2006.02.035
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发表时间：
2006-07-15
期刊：
影响因子：
5.7
通讯作者：
Owen, Adrian M.
中科院分区：
文献类型：
--
作者：
Dove, Anja;Brett, Matthew;Owen, Adrian M.
虽然在神经影像学研究中，前额叶皮层和内侧颞叶区域通常是共同激活的，但它们对人类记忆的确切贡献仍然不清楚。在这项与事件相关的功能性磁共振成像研究中，志愿者被要求简单地看抽象艺术的图片，而志愿者则被明确地要求记住类似的刺激，以便以后识别。在20名志愿者中，有19名志愿者在没有明确的记忆指令的情况下观看，其内侧颞叶的信号强度显著增加，但在中腹外侧前额叶皮层的一个区域却没有，该区域以前与记忆编码和提取有关。在扫描仪外收集的相同任务的行为数据显示，这些刺激的识别，但是，以上的机会。当任务指令被改变以鼓励志愿者记住刺激时，在双侧中腹外侧额叶皮层观察到信号强度的显着增加，但在内侧颞叶区域内没有伴随的增加。此外，在扫描仪外收集的行为数据证实，相对于“刚刚接受”的试验，对这些刺激的识别得到了显着改善。这些结果表明，中腹外侧额叶皮层和内侧颞叶区域对人类记忆的贡献是不可分离的，分别与“自上而下”和“自下而上”的认知控制概念密切相关。(c)2006年爱思唯尔公司All rights reserved.
Although the prefrontal cortex and regions of the medial temporal lobe are commonly co-activated in neuroimaging studies, their precise respective contributions to human memory remain unclear. In this event-related fMRI study, conditions requiring volunteers to simply look at pictures of abstract art were compared with conditions in which they were explicitly instructed to remember similar stimuli for later recognition. Looking, with no explicit instruction to remember, was associated with significant increases in signal intensity in the medial temporal lobe in 19 of the 20 volunteers scanned, but not in a region of the mid-ventrolateral prefrontal cortex that has previously been implicated in memory encoding and retrieval. Behavioral data collected outside the scanner on the same task revealed that recognition of these stimuli was, however, above chance. When the task instructions were changed to encourage the volunteers to remember the stimuli, significant increases in signal intensity were observed bilaterally, in the mid-ventrolateral frontal cortex, but there was no concomitant increase within the medial temporal lobe region. Moreover, behavioral data collected outside the scanner confirmed that recognition of these stimuli was significantly improved relative to the 'just took' trials. These results suggest that the mid-ventrolateral frontal cortex and the medial temporal lobe region make dissociable contributions to human memory that correspond closely to 'top-down' and 'bottom-up' notions of cognitive control, respectively. (c) 2006 Elsevier Inc. All rights reserved.