Relation of serum antibody to glycoproteins of respiratory syncytial virus with immunity to infection in children.
Relation of serum antibody to glycoproteins of respiratory syncytial virus with immunity to infection in children.
复制标题
呼吸道合胞病毒糖蛋白血清抗体与儿童感染免疫力的关系
DOI：
10.1089/vim.1987.1.199
复制
发表时间：
1987
期刊：
影响因子：
2.2
通讯作者：
Glezen,WP
中科院分区：
文献类型：
--
作者：
Kasel,JA;Walsh,EE;Frank,AL;Baxter,BD;Taber,LH;Glezen,WP
在 34 名儿童中测定了与被动转移的母体和自然诱导的针对病毒蛋白的血清抗体相关的免疫力，这些儿童从出生到三岁都接受呼吸道合胞病毒感染 (RSV) 的跟踪。使用 Long 菌株的附着蛋白和融合蛋白，通过免疫球蛋白类特异性酶联免疫吸附测定法对血清进行测试。通过比较 a) 7 名患有上呼吸道疾病的儿童与 12 名患有下呼吸道疾病的儿童和 b) 13 名在出生后 6 个月内患有 RSV 相关疾病的儿童（其出生月份和大致日期的年龄与同期未感染的 11 名儿童）的抗体滴度分布来评估原发感染中母体抗体免疫的基础。通过比较 19 名在初次感染后一年内再次感染 RSV 的儿童与 15 名未记录再感染的儿童的抗体滴度来评估感染诱导的免疫力。滴度的统计分析表明，针对融合蛋白的抗体是免疫的重要相关因素。在所有三项比较中，RSV 疾病较少的儿童在感染前的 IgG 抗 F 滴度显着较高。 IgA 抗 F 或 IgG 与 IgA 抗 G 滴度之间没有观察到差异。
Immunity in relation to passively transferred maternal and naturally-induced serum antibody to the viral proteins was determined in 34 children who were followed from birth through three years of age for respiratory syncytial virus infection (RSV). Sera were tested by immunoglobulin class-specific enzyme-linked immunosorbent assay using the attachment and fusion proteins of the Long strain. The basis for immunity for maternal antibody in primary infection was assessed by a comparison of the distribution of antibody titers in a) 7 children who had an upper respiratory illness to 12 whose illness was accompanied by lower respiratory disease and of b) 13 children with an RSV-associated illness in the first 6 months of life who were age-matched as to month and approximate day of birth with 11 not infected in the same period. Infection induced immunity was evaluated by a comparison of antibody titers in 19 children who were reinfected with RSV in the year following their primary infection to 15 in whom reinfection was not documented. A statistical analysis of titers revealed that antibody to the fusion protein is an important correlate of immunity. In all three comparisons, the children with less RSV disease had significantly higher IgG anti-F titers prior to infection. No differences were observed between IgA anti-F or IgG and IgA anti-G titers.