Investigating the phenotypes and genotypes of breast cancer in women with African ancestry: The need for more genetic epidemiology
Investigating the phenotypes and genotypes of breast cancer in women with African ancestry: The need for more genetic epidemiology
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DOI：
10.1016/j.suc.2007.01.003
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发表时间：
2007-04-01
影响因子：
3.1
通讯作者：
Newman, Lisa A.
中科院分区：
文献类型：
--
作者：
Hayanga, Aworl J.;Newman, Lisa A.
非洲血统妇女与其他种族/民族背景妇女在乳腺癌发病率、死亡率和发病年龄方面的差异了解甚少。对发生在非洲妇女身上的遗传变异进行更全面的阐述，可能有助于更好地了解非洲裔美国妇女的这种疾病，并解释遗传混合对这种疾病表达变异的作用。由于财政和基础设施的限制，缺乏记录非洲癌症负担的大规模、基于人口的数据库。这类项目的发展将是一项重要的癌症控制和研究策略。
Disparities in incidence, mortality, and age of onset of breast cancer between women of African ancestry and women of other racial/ ethnic backgrounds are poorly understood. A more comprehensive elaboration of genetic variants that occur in African women may facilitate a better understanding of the disease in African American women and explain the role of genetic admixture on the variation in the expression of the disease. Large-scale, population-based databases that document the cancer burden of Africa are lacking because of financial and infrastructural limitations. The development of such programs would represent an important cancer control and research strategy.