Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases.
Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases.
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Src家族蛋白酪氨酸激酶：治疗心血管疾病的一个有希望的靶点
DOI：
10.7150/ijms.49241
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发表时间：
2021
影响因子：
3.6
通讯作者：
Zheng T
中科院分区：
文献类型：
--
作者：
Zhai Y;Yang J;Zhang J;Yang J;Li Q;Zheng T
The Src-family protein tyrosine kinases (SFKs), a subfamily of non-receptor tyrosine kinases, are ubiquitously expressed in various cell types. Numerous studies have suggested that SFKs are related to signal transduction in major cardiac physiological and pathological processes, it is the activity of SFKs that is connected with the maintenance of cardiovascular homeostasis. Upon stimulation of various injury factors or stress, the phosphorylation state of SFKs is changed, which has been found to modulate different cardiac pathological conditions, such as hypertension, coronary heart disease, ischemic heart disease, myocardial ischemia-reperfusion injury, arrhythmia and cardiomyopathy via regulating cell growth, differentiation, movement and function, electrophysiologic signals. This review summarizes the basic information about SFKs, updates its role in the different processes underlying the development of multiple cardiovascular diseases (CVDs), and highlights their potential role as disease biomarkers and therapeutic targets, which would help understand the pathophysiology of CVDs and promote the further potential clinical adhibition.
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影响因子：
--
作者：
Alexandar, V.;Nayar, Pradeep G.;Ahmed, Shiek S. S. J.
通讯作者：
Ahmed, Shiek S. S. J.
DOI：
10.1016/j.bbamcr.2016.10.022
发表时间：
2017-06-01
影响因子：
5.1
作者：
Anguita, Estefania;Villalobo, Antonio
通讯作者：
Villalobo, Antonio
影响因子：
7.3
作者：
Chen Y;Kennedy DJ;Ramakrishnan DP;Yang M;Huang W;Li Z;Xie Z;Chadwick AC;Sahoo D;Silverstein RL
通讯作者：
Silverstein RL
线粒体 Src 酪氨酸激酶通过调节复合物 I 活性和线粒体 ROS 生成在缺血预处理的心脏保护作用中发挥作用
影响因子：
3.3
作者：
Ge, H.;Zhao, M.;Xu, Z.
通讯作者：
Xu, Z.
影响因子：
9.1
作者：
HOOD W B JR
通讯作者：
HOOD W B JR