Asymptomatic carriage of intestinal Cryptosporidium in immunocompetent and immunodeficient children: A prospective study
Asymptomatic carriage of intestinal Cryptosporidium in immunocompetent and immunodeficient children: A prospective study
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DOI：
10.1097/00006454-199512000-00003
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发表时间：
1995-12-01
影响因子：
3.6
通讯作者：
Guandalini, S
中科院分区：
文献类型：
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作者：
PettoelloMantovani, M;DiMartino, L;Guandalini, S
我们前瞻性研究了一组无症状的儿童，78名免疫功能正常和50名免疫缺陷儿童，以记录在这样的人群中无症状携带隐孢子虫病的发病率。我们还调查了对携带无症状隐孢子虫病的儿童进行治疗是否有助于降低其胃肠道症状的风险以及感染性卵囊的脱落。还调查了常见肠道病原体（包括贾第虫）的多重感染的发生率。无症状的隐孢子虫病被记录在6.4%的免疫功能正常和22%的免疫缺陷儿童。在一个控制症状人群中，隐孢子虫被发现在4.4%的免疫功能正常和4.8%的免疫缺陷儿童。在2例人类免疫缺陷病毒感染的儿童中记录了隐孢子虫的无症状携带，其中1例也无症状地携带贾第鞭毛虫。螺旋霉素治疗（100 mg/kg，每日一次，共14天）显著缩短了潜在感染性卵囊脱落的持续时间。最后，无症状隐孢子虫感染治疗的儿童未出现胃肠道症状，而未治疗的儿童出现胃肠道症状。
Little information is available on asymptomatic carriage of Cryptosporidium in immunocompetent and immunodeficient children, We prospectively studied a group of asymptomatic children, 78 immunocompetent and 50 immunodeficient, to document the incidence of asymptomatic carriage of cyptosporidiosis in such a population. We also investigated whether the treatment of children who carried asymptomatic cryptosporidiosis could help in reducing their risk of gastrointestinal symptoms as well as the shedding of infectious oocysts. The occurrence of multiple infections with common intestinal pathogens including Giardia lamblia was also investigated. Asymptomatic cryptosporidiosis was documented in 6.4% of immunocompetent and 22% of immunodeficient children. In a control symptomatic population Cryptosporidium was found in 4.4% of immunocompetent and 4.8% of immunodeficient children. Asymptomatic carriage of Cryptosporidium was documented in 2 human immunodeficiency virus-infected children, one of whom also carried Giardia asymptomatically. Treatment with spiramycin (100 mg/kg daily for 14 days) reduced significantly the duration of the shedding of potentially infectious oocysts, Finally no gastrointestinal symptoms developed in children treated for asymptomatic infection with Cryptosporidium, whereas children who were not treated developed gastrointestinal symptoms.