Noninvasive evaluation of cerebral glioma grade by using multivoxel 3D proton MR spectroscopy
Noninvasive evaluation of cerebral glioma grade by using multivoxel 3D proton MR spectroscopy
复制标题
利用多体素3D质子磁共振波谱无创评估脑胶质瘤分级
DOI：
10.1016/j.mri.2010.07.017
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发表时间：
2011-01-01
影响因子：
2.5
通讯作者：
Zhou, GengYin
中科院分区：
文献类型：
--
作者：
Zeng, QingShi;Liu, HePeng;Zhou, GengYin
目的：确定低级别和高级别胶质瘤之间的多体素 3D 质子 MR 波谱 (H-1 MRS) 代谢物比率是否不同，并可能对胶质瘤分级有用。材料和方法：39 名疑似患有胶质瘤的患者（23 名男性和 16 名女性；22-75 岁；平均年龄，44.92+/-12.65 岁）接受了 3D 扫描H-1 夫人 考试。测量代谢物比率[胆碱（Cho）/肌酸（Cr）、N-乙酰天冬氨酸（NAA）/Cr和Cho/NAA]。通过使用组织病理学分级来确定肿瘤分级。对代谢物比率进行受试者操作特征分析，并确定肿瘤分级的最佳阈值。计算了识别高级别神经胶质瘤的敏感性、特异性、阳性预测值 (PPV) 和阴性预测值 (NPV)。 结果：在 94.87% 的病例中获得了具有易于量化的 Cho、Cr 和 NAA 峰的诊断质量 3D H-1 MRS。高级别胶质瘤的 Cho/Cr 和 Cho/NAA 比值显着高于低级别胶质瘤 (P
Objective: To determine whether metabolite ratios in multivoxel 3D proton MR spectroscopy (H-1 MRS) is different between low-grade and high-grade gliomas and may be useful for glioma grading.Materials and Methods: Thirty-nine patients (23 male and 16 female; 22-75 years old; mean age, 44.92+/-12.65 years) suspected of having gliomas underwent 3D H-1 MRS examinations. Metabolite ratios [choline (Cho)/creatine (Cr), N-acetylaspartate (NAA)/Cr and Cho/NAA] were measured. Tumor grade was determined by using the histopathologic grading. Receiver operating characteristic analysis of metabolite ratios was performed, and optimum thresholds for tumor grading were determined. The resulting sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for identifying high-grade gliomas were calculated.Results: Diagnostic-quality 3D H-1 MRS with readily quantifiable Cho, Cr and NAA peaks was obtained in 94.87% of the cases. The Cho/Cr and Cho/NAA ratios were significantly higher in high-grade than in low-grade glioma (P