Haiti: Absence of dengue hemorrhagic fever despite hyperendemic dengue virus transmission
Haiti: Absence of dengue hemorrhagic fever despite hyperendemic dengue virus transmission
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DOI：
10.4269/ajtmh.2001.65.180
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发表时间：
2001-09-01
影响因子：
3.3
通讯作者：
Watts, DM
中科院分区：
文献类型：
--
作者：
Halstead, SB;Streit, TG;Watts, DM
1994-1996年，从发热的美国和其他联合国驻海地军事人员身上发现了185株1、2和4型登革热病毒。我们想知道是否存在登革出血热（DHF）的危险因素，如果是这样，登革出血热病例发生在海地儿童中。研究了海地太子港Carrefour区210名学龄儿童（6-13岁）的登革热传播率。当对血清进行针对DEN 1-4病毒的空斑减少中和抗体测试时，近85%的血清具有针对两种或更多种DEN血清型的抗体。年传播率估计为30%，在DHE海地DEN 2分离株流行的国家中观察到的传播率为基因型I，这与东南亚和美洲地区的DHF病例反复相关。尽管有积极的病毒学先决条件，登革出血热病例没有记录有经验的太子港儿科医生。这些观察结果让人想起了非洲的观察结果，为黑人群体中的登革热抗性基因提供了进一步的证据。
In 1994-1996, 185 strains of dengue (DEN) virus types 1, 2, and 4 were recovered from febrile United States and other United Nations military personnel in Haiti. We wondered whether risk factors for dengue hemorrhagic fever (DHF) existed and, if so, were DHF cases occurring among Haitian children. Dengue transmission rates were studied in 210 school children (6-13 years old) resident in Carrefour Borough, Port-au-Prince, Haiti. When sera were tested for plaque-reduction neutralizing antibodies to DEN 1-4 viruses, nearly 85% had antibodies to two or more DEN serotypes. The annual transmission rate was estimated at 30%, a rate observed in countries endemic for DHE Haitian DEN 2 isolates were genotype I, which are repeatedly associated with DHF cases in Southeast Asia and American regions. Despite positive virologic pre-conditions, DHF cases were not recorded by experienced Port-au-Prince pediatricians. These observations, which are reminiscent of those in Africa, provide further evidence of a dengue resistance gene in black populations.