SERUM DOPAMINE-BETA-HYDROXYLASE - DECREASE AFTER CHEMICAL SYMPATHECTOMY
SERUM DOPAMINE-BETA-HYDROXYLASE - DECREASE AFTER CHEMICAL SYMPATHECTOMY
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DOI：
10.1126/science.173.4000.931
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发表时间：
1971-01-01
期刊：
影响因子：
56.9
通讯作者：
AXELROD, J
中科院分区：
文献类型：
--
作者：
WEINSHILBOUM, R;AXELROD, J
多巴胺-β-羟化酶是一种定位于交感神经和肾上腺髓质中含有儿茶酚胺的小泡的酶，也存在于血清中。用6-羟多巴胺（一种破坏交感神经末梢的药物）治疗大鼠，导致血清多巴胺-β-羟化酶活性降低。这种减少不是由于对肾上腺髓质的影响或循环抑制剂或酶抑制剂的增加。这些数据表明，至少有一部分循环多巴胺-β-羟化酶活性来自交感神经末梢。
Dopamine-β-hydroxylase is an enzyme that is localized to catecholamine-containing vesicles in sympathetic nerves and the adrenal medulla, and is also found in the serum. Treatment of rats with 6-hydroxydopamine, a drug which destroys sympathetic nerve terminals, leads to a decrease in serum dopamine-β-hydroxylase activity. The decrease is not due to an effect on the adrenal medulla or to an increase in circulating inhibitor or inhibitors of enzyme. These data represent evidence that at least a portion of the circulating dopamine-β-hydroxylase activity arises from sympathetic nerve terminals.