MicroRNA-7 Is Associated with Malignant Potential and Poor Prognosis in Human Colorectal Cancer
MicroRNA-7 Is Associated with Malignant Potential and Poor Prognosis in Human Colorectal Cancer
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DOI：
10.21873/anticanres.11253
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发表时间：
2016-12-01
影响因子：
2
通讯作者：
Kusunoki, Masato
中科院分区：
文献类型：
--
作者：
Nagano, Yuka;Toiyama, Yuji;Kusunoki, Masato
microRNA-7（miR-7）的失调模式及其在结直肠癌（CRC）中表达的临床意义尚未解决。在这里，我们研究了临床病理因素，包括预后结果，和miR-7在结直肠癌组织中的表达之间的关系。我们通过实时逆转录聚合酶链反应分析了210例结直肠组织（196例CRC和14例健康志愿者的正常粘膜）中miR-7的表达水平。与正常结直肠粘膜相比，CRC组织中miR-7表达水平显著上调。miR-7的高表达与肿瘤深度、静脉浸润、淋巴浸润、淋巴结转移和肝转移显著相关。高miR-7表达与CRC患者的总生存率显著相关（p=0.010）。此外，miR-7表达是CRC患者的独立预后因素（风险比=1.854，95%置信区间=1.016-3.540; p=0.044）。miR-7在CRC中作为癌基因，与肿瘤进展和不良预后显著相关。
Dysregulation pattern of microRNA-7 (miR-7) and the clinical significance of its expression in colorectal cancer (CRC) are unresolved. Here, we investigated the relationship between clinicopathological factors, including prognostic outcome, and miR-7 expression in CRC tissues. We analyzed miR-7 expression levels by real-time reverse transcription polymerase chain reaction in 210 colorectal tissues (196 CRCs and 14 normal mucosae from healthy volunteers). miR-7 expression levels were significantly upregulated in CRC tissues compared to normal colorectal mucosae. Elevated miR-7 expression was significantly correlated with tumour depth, venous invasion, lymphatic invasion, lymph node metastasis, and liver metastasis. High miR-7 expression was significantly associated with poor overall survival in patients with CRC (p=0.010). Moreover, miR-7 expression was an independent prognostic factor in patients with CRC (hazard ratio=1.854, 95% confidence interval=1.016-3.540; p=0.044). miR-7 acts as an oncogene in CRC and is significantly associated with tumour progression and poor prognosis.