Mast cells squeeze the heart and stretch the gird: their role in atherosclerosis and obesity.
Mast cells squeeze the heart and stretch the gird: their role in atherosclerosis and obesity.
复制标题
肥大细胞挤压心脏并拉伸心脏：它们在动脉粥样硬化和肥胖中的作用。
DOI：
10.1016/j.tips.2011.05.005
复制
发表时间：
2011
影响因子：
13.8
通讯作者：
Kalogeromitros,Dimitrios
中科院分区：
文献类型：
--
作者：
Theoharides,TheoharisC;Sismanopoulos,Nikolaos;Delivanis,Danae-Anastasia;Zhang,Bodi;Hatziagelaki,ErifiliE;Kalogeromitros,Dimitrios
肥大细胞对过敏和过敏性反应的发展至关重要，但它们也参与获得性和先天免疫。越来越多的证据表明肥大细胞在炎症性疾病中是通过非过敏性触发因素（如神经肽和细胞因子）激活的。本文综述了肥大细胞如何参与与冠状动脉疾病和肥胖相关的炎症过程。动物模型表明，肥大细胞通过分泌各种血管活性介质、细胞因子和蛋白酶，促进冠状动脉斑块的进展和不稳定，以及饮食诱导的肥胖和糖尿病。了解肥大细胞如何参与这些炎症过程可能有助于开发具有新治疗应用的独特抑制剂，这些疾病构成当前对全球人类健康和福祉的最大威胁。
Mast cells are crucial for the development of allergic and anaphylactic reactions, but they are also involved in acquired and innate immunity. Increasing evidence now implicates mast cells in inflammatory diseases through activation by non-allergic triggers such as neuropeptides and cytokines. This review discusses how mast cells contribute to the inflammatory processes associated with coronary artery disease and obesity. Animal models indicate that mast cells, through the secretion of various vasoactive mediators, cytokines and proteinases, contribute to coronary plaque progression and destabilization, as well as to diet-induced obesity and diabetes. Understanding how mast cells participate in these inflammatory processes could help in the development of unique inhibitors with novel therapeutic applications for these diseases, which constitute the greatest current threat to global human health and welfare.