Identifying phases of investigation helps planning, appraising, and applying the results of explanatory prognosis studies
Identifying phases of investigation helps planning, appraising, and applying the results of explanatory prognosis studies
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DOI：
10.1016/j.jclinepi.2007.08.005
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发表时间：
2008-06-01
影响因子：
7.2
通讯作者：
Bombardier, C.
中科院分区：
文献类型：
--
作者：
Hayden, J. A.;Cote, P.;Bombardier, C.
目的：为了提出一个解释性框架，了解预后，并说明它使用的数据从systematic review.Study Design and Setting：一个框架，包括三个阶段的解释性预后调查是适应从早期的工作和因果关系的理解进行了综合讨论。为了说明，预后研究是从1966年至2006年12月的电子和补充文献检索中确定的。我们提取了人群、暴露和结局的特征，并确定了解释性预后研究的三个阶段：第一阶段，确定相关性;第二阶段，测试独立相关性;第三阶段，理解预后途径。每个阶段的目的分别是探索、确认和发展理解。结果：重要的是考虑解释性预后研究的框架：（1）确定研究目标，（2）介绍研究方法和数据，（3）解释和应用研究结果。结论：在进行和报告预后研究时，研究人员应考虑预后方法（解释性或结果预测）和研究阶段，使用最佳方法限制偏倚，完整报告，并谨慎解释结果。这样，卫生保健研究的读者将能够更好地评估目标，解释和适当地使用预后研究的结果。(c)2008年爱思唯尔公司All rights reserved.
Objective: To present an explanatory framework for understanding prognosis and illustrate it using data from a systematic review.Study Design and Setting: A framework including three phases of explanatory prognosis investigation was adapted from earlier work and a discussion of causal understanding was integrated. For illustration, prognosis studies were identified from electronic and supplemental searches of literature between 1966 and December 2006. We extracted characteristics of the populations, exposures, and outcomes and identified three phases of explanatory prognosis investigation: Phase 1, identifying associations; Phase 2, testing independent associations; and Phase 3, understanding prognostic pathways. The purpose of each phase is exploration, confirmation, and development of understanding, respectively.Results: It is important to consider a framework of explanatory prognosis studies for: (1) defining the study objectives, (2) presenting the study methods and data, and (3) interpreting and applying the results of the study.Conclusion: When conducting and reporting prognosis studies, researchers should consider the approach to prognosis (explanatory or outcome prediction) and phase of investigation, use best methods to limit biases, report completely, and cautiously interpret results. Readers of health care research will then be better able to evaluate the goals and interpret and appropriately use the results of prognosis studies. (c) 2008 Elsevier Inc. All rights reserved.