Autophagy in Health and Food Science
Autophagy in Health and Food Science
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DOI：
10.1007/s40495-020-00237-2
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发表时间：
2020-09
影响因子：
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通讯作者：
S. Yano;Jinyun Wang;Taichi Hara
中科院分区：
文献类型：
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作者：
S. Yano;Jinyun Wang;Taichi Hara
综述目的近年来，全球范围内的老龄化人口不断增加，导致人们对日益严重的健康问题的担忧。预防医学在延长老龄化社会的健康预期寿命方面发挥着重要作用，对功能性食品的需求日益增加，这些食品可以在健康受损之前长时间摄入。本文就自噬在疾病预防和抗衰老中的作用作一综述。自噬是一种细胞内降解系统，通过循环利用细胞内成分，有助于维持健康和预防疾病的发生。最近的证据表明，自噬在延长健康寿命方面发挥着潜在的作用。自噬活性下降与衰老有关，导致各种年龄相关疾病的发生，如神经变性。相反，具有人工增强的自噬活性的动物模型已经证明了延长的寿命，同时保持了进行运动的能力。因此，自噬的增强预计将有助于促进健康。虽然先前的研究已经描述了上调的自噬的食物，其中几个还没有被评估使用适当的methods.SummaryThis本文的重点是自噬，这是密切相关的健康维护和疾病的预防，并总结了最近的研究在自噬的功能，食物和延长健康寿命从健康和食品科学的观点。
Purpose of ReviewIn recent years, the aging population in society has been increasing on a global scale, leading to concerns regarding increasing health problems. Preventive medicine plays a major role in extending healthy life expectancy in aging societies, and there is an increasing demand for functional foods that can be ingested for a long period of time before health is impaired. The aim of the present review is to briefly elucidate the role of autophagy in disease prevention and anti-aging. The application of autophagy in health promotion using functional foods has also been discussed.Recent FindingsAutophagy is an intracellular degradation system that contributes to the maintenance of health and prevention of disease onset by recycling intracellular components. Recent evidence has shown that autophagy plays a potential role in extending health span. Autophagic activity decline has been associated with aging, leading to the onset of various age-associated diseases such as neurodegeneration. Conversely, animal models with artificially enhanced autophagic activity have demonstrated an extended lifespan while maintaining the ability to perform exercise. Therefore, the enhancement of autophagy is anticipated to contribute to health promotion. Although prior studies have described the upregulation of autophagy by food, several of them have not been evaluated using an appropriate method.SummaryThis paper focuses on autophagy, which is closely related to health maintenance and disease prevention, and summarizes recent studies on the function of food in autophagy and on extending health span from the viewpoint of health and food science.