Acute changes in serum gonadotrophins and steroids following orchidectomy in the rat: role of the adrenal gland.
Acute changes in serum gonadotrophins and steroids following orchidectomy in the rat: role of the adrenal gland.
复制标题
大鼠睾丸切除术后血清促性腺激素和类固醇的急性变化：肾上腺的作用。
DOI：
10.1210/endo-100-6-1550
复制
发表时间：
1977
期刊：
影响因子：
4.8
通讯作者：
S. Justo
中科院分区：
文献类型：
--
作者：
N. Schwartz;S. Justo
雄性大鼠睾丸切除术导致a) 9h内血清LH和FSH升高；B)血清睾酮下降至基线水平30分钟；C)在肾上腺存在的情况下，血清黄体酮升高（持续30 ~ 120分钟）。如果肾上腺切除术与睾丸切除术同时进行，9和12 h的LH和FSH升高被消除，24 h的升高被减弱或消除。到48小时，去睾丸肾上腺大鼠的血清LH和FSH的升高与单独去性腺的大鼠相当。有两种假设可以解释睾丸素-肾上腺素联合治疗后早期促性腺激素升高的消失：a)早期反应是由于在睾酮降低的背景下血清黄体酮升高；b)由于缺少皮质酮，早期反应被取消，这要么迫使垂体分泌ACTH和LH/FSH之间的竞争，要么是快速促性腺激素分泌反应所必需的。讨论了在肾上腺存在或不存在的情况下，雄性和雌性大鼠在LH和FSH对性腺切除术的反应方面的异同。
Orchidectomy in male rats leads to a) an increase in serum LH and FSH within 9 h; b) a decrease in serum testosterone to baseline levels by 30 min; c) an increase in serum progesterone (for 30 to 120 min), in the presence of the adrenals. If adrenalectomy is performed simultaneously with orchidectomy, the LH and FSH rises at 9 and 12 h are abolished, and the rises at 24 h are attenuated or abolished. By 48 h, the orchidectomized-adrenalectomized rat has achieved a rise in serum LH and FSH equal to that found in gonadectomy alone. Two hypotheses are offered to explain the abolition of the early gonadotrophin rises after combined orchidectomy-adrenalectomy treatment: a) the early responses are due to increased serum progesterone, on a background of decreased testosterone; b) the early responses are abolished because of the missing corticosterone, which either forces competition between pituitary secretion of ACTH and LH/FSH, or is necessary for rapid gonadotroph-secretory response. The differences and similarities between male and female rats, in the response of LH and FSH to gonadectomy, in the presence or absence of the adrenals, are discussed.