Importance of optimal local uterine blood flow for implantation
Importance of optimal local uterine blood flow for implantation
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DOI：
10.1111/jog.12418
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发表时间：
2014-06-01
影响因子：
1.6
通讯作者：
Kimura, Tadashi
中科院分区：
文献类型：
--
作者：
Nakamura, Hitomi;Hosono, Takayoshi;Kimura, Tadashi
目的本研究的目的是确定子宫血流量是否是预测子宫接受性的有效参数。材料与方法利用植入过程中信号换能器和转录-3激活因子的瞬时和局部抑制，测定了妊娠早期小鼠子宫内膜和子宫外的局部子宫血流量。结果配种后子宫局部血流量显著增加，随着着床时间的延长而减少。信号换能器和转录-3诱骗物激活物转染小鼠交媾后2.5 d子宫局部血流量显著高于对照组。然而，个别数值的范围太大，无法找到一个分界点。结论应减少排卵后局部子宫血流量，为打开着床窗做准备。妊娠期子宫局部最佳血流量受时间事件的调节。使用激光多普勒血流计，子宫血流的个体值范围很广。这个参数本身可能不是评价子宫容受性前景的合适参数。
Aims The aim of this study was to determine whether uterine blood flow is an effective parameter to anticipate uterine receptivity. Material and Methods The local uterine blood flow was measured in the endometrium and on the outside of the uterus in mice during the early stage of pregnancy and an implantation failure mouse model using transient and local suppression of signal transducer and activator of transcription-3 activity during implantation. Results The local uterine blood flow was dramatically increased after mating and was decreased towards the time of implantation. The local uterine blood flow at 2.5 days post-coitus in signal transducer and activator of transcription-3 decoy transferred mice was significantly higher than in control mice. However, the range of individual values was too wide to find a cut-off point. Conclusions It is necessary to decrease local uterine blood flow after ovulation to prepare the opening implantation window. The optimal local uterine blood flow is regulated by time events during pregnancy. The range of individual values of uterine blood flow is wide using a laser Doppler blood flow meter. This parameter itself may not be an appropriate parameter to evaluate the prospect of uterine receptivity.