A single gene encoding vitellogenin in the sea urchin Strongylocentrotus purpuratus: sequence at the 5' end.
A single gene encoding vitellogenin in the sea urchin Strongylocentrotus purpuratus: sequence at the 5' end.
复制标题
海胆 Strongylocentrotus purpuratus 中编码卵黄蛋白原的单个基因：5 端序列。
DOI：
10.1093/nar/15.24.10405
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发表时间：
1987
影响因子：
14.9
通讯作者：
Raff,RA
中科院分区：
文献类型：
--
作者：
Shyu,AB;Blumenthal,T;Raff,RA
紫海胆卵黄蛋白原(卵黄蛋白前体)的合成是独一无二的，因为雄性和雌性都能产生高水平的卵黄蛋白。在这篇文章中，我们证明了这种生物也是独一无二的，只有一个卵黄蛋白原基因。就像脊椎动物中编码类似旋转蛋白的基因一样，海胆基因很大，大约有19kb。该基因5‘端周围的序列揭示了与脊椎动物卵黄蛋白原基因的其他几个相似之处：信号序列非常短，具有与青蛙和鸡的序列相似的序列；在−32有一个典型的TATA框；在−207有一个与雌激素反应元件非常相似的序列。
The synthesis of vitellogenin (yolk protein precursor) in the sea urchin,Strongylocentrotus purpuratus, is unique in that both males and females produce a high level of the protein. In this paper we show that this organism also is unique in possessing only a single vitellogenin gene. Like the genes that encode analogous roteins in vertebrates, the sea urchin gene is large, about 19 kb in length. The sequence surrounding the 5′ end of the gene revealed several other similarities to vertebrate vitellogenin genes: the signal sequence is exceptionally short and has a sequence similar to those from frog and chick; there is a canonical TATA box at −32; and there is a sequence closely resembling the estrogen-responsive element at −207.