Upper cervical spinal cord cross-sectional area in relapsing remitting multiple sclerosis: Application of a new technique for measuring cross-sectional area on magnetic resonance images
Upper cervical spinal cord cross-sectional area in relapsing remitting multiple sclerosis: Application of a new technique for measuring cross-sectional area on magnetic resonance images
复制标题
DOI：
10.1002/jmri.20959
复制
发表时间：
2007-07-01
影响因子：
4.4
通讯作者：
Tench, Christopher R.
中科院分区：
文献类型：
--
作者：
Mann, Ranbir S.;Constantinescu, Cris S.;Tench, Christopher R.
目的：准确测量复发缓解型多发性硬化症（RRMS）患者和正常对照受试者的上颈髓横截面积（CSA），以解决以下悖论：在RRMS中检测到CSA纵向减少，而与对照组相比则没有减少。我们假设，缺乏统计权力和/或测量灵敏度，由于部分体积平均在以前的研究促成了这一paradox.Materials和方法：使用的技术，纠正部分体积平均，我们测量了CSA在35名正常对照组和35名，RRMS患者。W，e使用总颅内容积（TICV）来标准化CSA，从而降低了正态方差并提高了统计学功效。统计功效分析表明，患者中CSA降低5%，在正常化之前估计功效为0.74，在正常化之后估计功效为0.9。与正常对照组相比，患者的平均CSA在标准化后（P = 0.928）或标准化前（P = 0.881）没有降低。结论：使用敏感的分析方法和明显适当的统计功效，我们没有检测到RRMS患者的CSA降低。我们推测这可能是由于炎症。
Purpose: To measure accurately the upper cervical cord cross-sectional area (CSA) in patients with relapsing remitting multiple sclerosis (RRMS), and normal control subjects, to address the paradox that longitudinal reduction in CSA has been detected in RRMS while reduction compared,, to controls has not. We hypothesized that a lack of statistical power and/or measurement sensitivity due to partial volume averaging in previous studies contributed to this paradox.Materials and Methods: Using a technique that corrects for partial volume averaging, we measured the CSA in 35 normal controls and 35,RRMS patients,.,W,e used the total intracranial volume(TICV) to normalize the CSA and therefore reduce the normal variance and improve the statistical power.Results: The mean TICV did not differ between groups. Statistical power analysis indicated that a 5% reduction in CSA in the patients,could be an, estimated power of 0.74 before normalization and 0.9 after. The mean CSA in the patients was not reduced compared to controls after (P = 0.928) or before (P = 0.881) normalization.Conclusion: Using a,sensi ive analysis method, and apparently appropriate statistical,power,we did not detect reduced CSA in RRMS patients. We hypothesize that this may be due to inflammation.