Apoptotic pathways in ischemic acute renal failure
Apoptotic pathways in ischemic acute renal failure
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DOI：
10.1111/j.1523-1755.2004.761_6.x
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发表时间：
2004-08-01
影响因子：
19.6
通讯作者：
Shah, SV
中科院分区：
文献类型：
--
作者：
Kaushal, GP;Basnakian, AG;Shah, SV
细胞死亡的研究已经成为细胞生物学研究的一个重要和令人兴奋的领域。虽然两种类型的细胞死亡，细胞凋亡和坏死，是公认的，在我们的理解细胞死亡的主要进展之一已经认识到，传统上与细胞凋亡相关的途径可能是非常关键的形式与坏死相关的细胞损伤。缺血引起的肾小管上皮细胞损伤通常被认为是细胞坏死的结果。我们简要描述了最近的证据表明，通常与细胞凋亡，包括核酸内切酶激活，线粒体和半胱天冬酶的作用，是重要的肾小管损伤的途径。很可能导致细胞凋亡或坏死模式的级联几乎同时被激活，并且可能共享一些共同的途径。
The study of cell death has emerged as an important and exciting area of research in cell biology. Although two kinds of cell death, apoptosis and necrosis, are recognized, one of the major advances in our understanding of cell death has been the recognition that the pathways traditionally associated with apoptosis may be very critical in the form of cell injury associated with necrosis. Renal tubular epithelial cell injury from ischemia has been generally regarded as a result of necrotic form of cell death. We briefly describe recent evidence indicating that pathways generally associated with apoptosis, including endonuclease activation, role of mitochondria and caspases, are important in renal tubular injury. It is likely that the cascades that lead to apoptotic or necrotic mode of cell death are activated almost simultaneously and may share some common pathways.