Mitochondria Initiate and Regulate Sarcopenia.
Mitochondria Initiate and Regulate Sarcopenia.
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DOI：
10.1249/jes.0000000000000101
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发表时间：
2017-04
影响因子：
5.7
通讯作者：
Myers MJ
中科院分区：
文献类型：
--
作者：
Alway SE;Mohamed JS;Myers MJ
我们提出了一个假设，即功能障碍的线粒体的积累启动了一个信号级联反应，导致运动神经元和肌纤维死亡，并最终在肌肉减少症。含有功能障碍的线粒体的神经细胞和肌肉细胞之间的相互作用加剧了肌肉减少症。预防肌肉减少症将需要确定可逆的功能障碍的线粒体来源。TOC总结：肌肉减少症的特征为纤维萎缩和纤维丢失。线粒体健康决定死亡信号，导致局部蛋白质损失，如果不加控制，则会导致肌肉纤维的广泛损失。
We present the hypothesis that an accumulation of dysfunctional mitochondria initiates a signaling cascade leading to motor neuron and muscle fiber death and culminating in sarcopenia. Interactions between neural and muscle cells that contain dysfunctional mitochondria exacerbate sarcopenia. Preventing sarcopenia will require identifying mitochondrial sources of dysfunction that are reversible. Summary for TOC: Sarcopenia is characterized by fiber atrophy and loss of fibers. Mitochondria health determine death signaling leading to localized protein loss and if unchecked, widespread loss of muscle fibers.