Neonatal whisker removal in rats stabilizes a transient projection from the auditory thalamus to the primary somatosensory cortex.
Neonatal whisker removal in rats stabilizes a transient projection from the auditory thalamus to the primary somatosensory cortex.
复制标题
去除大鼠新生胡须可稳定从听觉丘脑到初级体感皮层的短暂投射。
DOI：
10.1016/0006-8993(91)91445-7
复制
发表时间：
1991
期刊：
影响因子：
2.9
通讯作者：
Lin,RC
中科院分区：
文献类型：
--
作者：
Nicolelis,MA;Chapin,JK;Lin,RC
一个正常的短暂的跨模态丘脑皮质投射从内侧膝状体核（MGm）的大细胞亚部的初级躯体感觉（SI）皮层的大鼠被发现保持不变，在整个成年期后，在新生动物的胡须单侧删除。正常的MGm投射到听觉皮层并没有在这些小脑须剥夺的成年大鼠中丢失，但是一些MGm神经元向初级听觉和SI皮层发送侧支。平行的电生理实验表明，多模式的一些MGm神经元，因为它们响应听觉和皮肤刺激。这些结果表明，区域分布在皮质的丘脑皮质的预测所产生的多模式丘脑核，如MGm，可以确定在出生后早期的发展过程中的感觉信息的正常流动从外周丘脑和出生后早期的躯体感觉剥夺可能会阻止正常撤回的跨模态投影从MGm到SI。
A normally transient cross-modal thalamocortical projection from the magnocellular subdivision of the medial geniculate nucleus (MGm) to the primary somatosensory (SI) cortex of rats was found to remain unchanged throughout adulthood following unilateral removal of whiskers in newborn animals. The normal MGm projection to the auditory cortex is not lost in these neonatally whisker-deprived adults rats but some of the MGm neurons send collaterals to both primary auditory and SI cortices. Parallel electrophysiological experiments demonstrated the multimodal character of some MGm neurons, since they responded to both auditory and cutaneous stimulation. These results suggest that the areal distribution in the cortex of thalamocortical projections arising from a multimodal thalamic nucleus, such as the MGm, may be determined during early postnatal development by the normal flow of sensory information from the periphery to the thalamus and that an early postnatal somatosensory deprivation may prevent the normal withdrawal of a cross-modal projection from the MGm to the SI.