Guanfacine Use in Children With Down Syndrome and Comorbid Attention-Deficit Hyperactivity Disorder (ADHD) With Disruptive Behaviors
Guanfacine Use in Children With Down Syndrome and Comorbid Attention-Deficit Hyperactivity Disorder (ADHD) With Disruptive Behaviors
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DOI：
10.1177/0883073816634854
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发表时间：
2016-07-01
影响因子：
1.9
通讯作者：
Bay, Mihee
中科院分区：
文献类型：
--
作者：
Capone, George T.;Brecher, Liza;Bay, Mihee
本研究的目的是使用异常行为检查表（ABC）来描述唐氏综合征和注意缺陷多动障碍（ADHD）儿童的破坏性行为，并测量胍法辛对适应不良行为的治疗效果。受试者从2002年至2007年期间访问我们诊所的一组门诊患者中招募。受试者（N = 23）为4至12岁（平均7.4 +/- 4.1）的唐氏综合征儿童，符合精神障碍诊断和统计手册第四版的ADHD标准。异常行为检查表、易怒和多动子量表在随访时均显示显著降低（P < .0001）。多动平均下降25%（-7.8分），易怒平均下降25%（-3.5分）。平均综合评分也下降了24%（-12分）。易怒的效应量差异是中等的，而多动和综合评分的差异似乎很大。临床上重要的目标行为减少。药物的耐受性一般良好，治疗后出现的副作用的发生率仍然很低。
The purpose of this study was to characterize children with Down syndrome and attention-deficit hyperactivity disorder (ADHD) with disruptive behaviors using the Aberrant Behavior Checklist (ABC), and to measure the treatment effects of guanfacine on maladaptive behaviors. Subjects were enrolled from a group of outpatients who visited our clinic between 2002 and 2007. Subjects (N = 23) were children with Down syndrome ages 4 to 12 years (mean 7.4 +/- 4.1), who met criteria for ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The Aberrant Behavior Checklist Irritability and Hyperactivity subscales each showed a significant decrease (P < .0001) at follow-up. The mean decline on Hyperactivity was 25% (-7.8 points), and for Irritability, 25% (-3.5 points). The mean composite score also declined by 24% (-12 points). Effect size differences on Irritability were moderate, whereas differences on Hyperactivity and composite score appeared large. Clinically important target behaviors were reduced. Medication was generally well tolerated and the incidence of treatment emergent side effects remained low.