ULTRASOUND SHEAR-WAVE ELASTOGRAPHY OF THE TONGUE IN ADULTS WITH OBSTRUCTIVE SLEEP APNEA
ULTRASOUND SHEAR-WAVE ELASTOGRAPHY OF THE TONGUE IN ADULTS WITH OBSTRUCTIVE SLEEP APNEA
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DOI：
10.1016/j.ultrasmedbio.2020.03.022
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发表时间：
2020-07-01
影响因子：
2.9
通讯作者：
Chen, Jeng-Wen
中科院分区：
文献类型：
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作者：
Chang, Chun-Hsiang;Huang, Chih-Chung;Chen, Jeng-Wen
阻塞性睡眠呼吸暂停（OSA）是一种以间歇性睡眠状态依赖性上呼吸道塌陷为特征的慢性呼吸障碍。舌部由初级UA扩张肌组成，在OSA发病中起重要作用。我们研究了使用超声（US）剪切波弹性成像（SWE）测量舌刚度是否有助于预测OSA的存在。46名参与者（20名健康对照和26名OSA患者）使用US系统进行了经皮颏下SWE。在正常呼吸和Muller's机动（MM）时，记录剪切模量0-200 kPa的量化。以多导睡眠图为参考标准。在正常呼吸和MM时，清醒OSA患者的中矢状舌僵硬度明显高于对照组（p < 0.0001）。OSA患者舌后三分之一的剪切模量在MM期间最高（p < 0.001）。MM时，全舌和后三分之一的截断值分别为27.6和35.2 kPa，检测OSA的灵敏度分别为69.2%和76.9%，特异性分别为85%和95%。受试者工作特征曲线下相应面积分别为0.82和0.88。usswe可能具有无创测量OSA患者舌刚度的潜力。（电子邮件地址：chen.jw@msa.hinet.net, 086365@mail.fju.edu.tw） (c) 2020年世界超声医学与生物学联合会。版权所有。
Obstructive sleep apnea (OSA) is a chronic breathing disorder characterized by intermittent sleep state-dependent upper airway (UA) collapse. The tongue comprises the primary UA dilator muscle and plays an essential role in the pathogenesis of OSA. We examined whether tongue stiffness measurement using ultrasound (US) shear wave elastography (SWE) is useful for predicting the existence of OSA. Forty-six participants (20 healthy controls and 26 patients with OSA) underwent transcutaneous submental SWE using a US system. Quantification with a shear modulus of 0-200 kPa was recorded during normal breathing and Muller's maneuver (MM). Polysomnography was used as the reference standard. Mid-sagittal tongue stiffness was significantly higher in awake patients with OSA than in controls during normal breathing and the MM (p < 0.0001). The posterior third of the tongue in patients with OSA had the highest value of shear modulus during the MM (p < 0.001). With cut-offs of 27.6 and 35.2 kPa for the whole tongue and posterior third during the MM, respectively, the sensitivity obtained was 69.2% and 76.9%, and the specificity was 85% and 95%, respectively, for detecting OSA. The corresponding areas under the receiver operating characteristic curve were 0.82 and 0.88, respectively. US SWE may have the potential for non-invasive tongue stiffness measurement in OSA. (E-mail addresses: chen.jw@msa.hinet.net, 086365@mail.fju.edu.tw) (c) 2020 World Federation for Ultrasound in Medicine & Biology. All rights reserved.