Evidence for a GABA-mediated cerebellar inhibition of the inferior olive in the cat
Evidence for a GABA-mediated cerebellar inhibition of the inferior olive in the cat
复制标题
GABA 介导的猫下橄榄小脑抑制的证据
作者：
Gert Andersson;M. Garwicz;G. Hesslow
摘要1.爬行纤维激活周围神经刺激在“高”频率（>3 Hz）为15-25秒，然后在0.9 Hz约1分钟。高频率激活诱导后调节抑制，持续约1分钟，从小脑表面记录的爬行纤维反应。2.在上级小脑脚（结合臂）中进行电解损伤。损伤后，后处理抑制完全消除。3.将GABA受体阻断剂甲碘荷包牡丹碱注射到下橄榄中可逆地阻断了后调节抑制。4.这些结果支持Andersson和Hesslow（1987 a）提出的假说，即后条件反射抑制是由GABA能中介橄榄通路介导的。
Summary1. Climbing fibres were activated by peripheral nerve stimulation at ‘high’ frequencies (>3 Hz) for 15–25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition is mediated by a GABA-ergic interposito-olivary pathway.