Mode of delivery is associated with asthma and allergy occurrences in children
Mode of delivery is associated with asthma and allergy occurrences in children
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DOI：
10.1016/j.annepidem.2005.06.054
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发表时间：
2006-05-01
影响因子：
5.6
通讯作者：
Gilliland, Frank D.
中科院分区：
文献类型：
--
作者：
Salam, Muhammad T.;Margolis, Helene G.;Gilliland, Frank D.
目的：越来越多的证据表明，围产期因素调节免疫发育，从而可能影响儿童哮喘风险。在这项研究中，我们检查了剖腹产（剖腹产）出生与儿童期特应性疾病发生之间的关联。 方法：受试者于 1975 年至 1987 年间出生于加利福尼亚州，参加儿童健康研究时年龄为 8 至 17 岁。根据出生证明数据，我们的分析仅限于 3464 名在妊娠 37 周或之后出生、出生体重为 2500 克或以上的儿童。有关社会人口因素、报告的医生诊断的哮喘和其他特应性疾病的信息是通过使用自我管理的结构化调查问卷获得的。拟合逻辑回归模型来计算比值比 (OR) 和 95% 置信区间 (Cls)。 结果：剖腹产儿童患哮喘（OR，1.33；95% Cl，1.01-1-75）、花粉症（OR，1.57；95% Cl，1.24-1.99）和过敏（OR，1.26；95%）的风险增加Cl，1.03-1.53）与阴道分娩的相比。无论哮喘或过敏家族史如何，儿童与剖腹产相关的风险都是相同的。结论：我们的结论是，剖腹产或与之相关的过程可能会增加儿童患特应性疾病的风险。
PURPOSE: A growing body of evidence indicates that perinatal factors modulate immune development and thereby may affect childhood asthma risk. In this study, we examined the associations between birth by cesarean section (C-section) and atopic disease occurrence in childhood.METHODS: Subjects were born in California between 1975 and 1987 and were 8 to 17 years old during their enrollment in the Children's Health Study. Our analysis was restricted to 3464 children born at or after 37 weeks of gestation with a birth weight of 2500 g or greater based on birth certificate data. Information about sociodemographic factors, reported physician-diagnosed asthma, and other atopic diseases was obtained by using a self-administered structured questionnaire. Logistic regression models were fitted to compute odds ratios (ORs) and 95% confidence intervals (Cls).RESULTS: Children born by C-section were at increased risk for asthma (OR, 1.33; 95% Cl, 1.01-1-75), hay fever (OR, 1.57; 95% Cl, 1.24-1.99), and allergy (OR, 1.26; 95% Cl, 1.03-1.53) compared with those born vaginally. Risk associated with C-section was the same for children regardless of family history of asthma or allergy.CONCLUSION: We conclude that birth by C-section or processes associated with it may increase the risk for atopic disease in childhood.