EPIDEMIOLOGY OF HELICOBACTER-PYLORI IN AN ASYMPTOMATIC POPULATION IN THE UNITED-STATES - EFFECT OF AGE, RACE, AND SOCIOECONOMIC-STATUS
EPIDEMIOLOGY OF HELICOBACTER-PYLORI IN AN ASYMPTOMATIC POPULATION IN THE UNITED-STATES - EFFECT OF AGE, RACE, AND SOCIOECONOMIC-STATUS
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DOI：
10.1016/0016-5085(91)90644-z
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发表时间：
1991-06-01
期刊：
影响因子：
29.4
通讯作者：
ADAM, E
中科院分区：
文献类型：
--
作者：
GRAHAM, DY;MALATY, HM;ADAM, E
幽门螺杆菌（以前的弯曲杆菌）在B型胃炎中的致病作用现在已被接受，而且越来越多的证据表明H.幽门感染在消化性溃疡疾病中起主要作用。初步研究报告称，幽门螺杆菌感染的患病率随着年龄的增长而增加，但有关该细菌在任何特定人群中的患病率以及可能影响分布模式的因素的详细信息仍然很少。在本研究中，采用灵敏的酶联免疫吸附试验和[13 C]尿素呼气试验来调查H的患病率。H. pylori感染在485名年龄在15岁和80岁之间的健康无症状志愿者中的居住在休斯敦大都市区。幽门螺杆菌感染占52%。H.幽门螺杆菌感染随着年龄的增长而迅速增加，总人口为1%/年。H.幽门螺杆菌感染在黑人（70%）高于白人（34%）（P< 0.001），在对年龄、性别、教育水平、收入和吸烟或饮酒进行调整后，这种差异仍然存在。幽门螺杆菌感染与性别无关，但与社会经济阶层密切相关。年龄校正的H.幽门螺杆菌感染与经济收入、文化程度与H.幽门感染H.幽门感染和饮酒或非甾体类药物使用或吸烟。养宠物与较低的H频率有关。幽门螺杆菌感染，但这是高度相关的较高的社会经济地位。H. pylori，但H.幽门螺杆菌感染与粪-口传播是一条重要途径相一致。社会经济因素似乎决定了收购的年龄。
A causative role is now accepted forHelicobacter(formerlyCampylobacter)pyloriin type B gastritis, and evidence is accumulating thatH. pyloriinfection plays a major contributory role in peptic ulcer disease. Preliminary studies have reported that the prevalence ofH pyloriinfection increases with age, but detailed information on the prevalence of the bacteria in any defined population and on the factors that may influence the pattern of distribution remains scanty. In the present study, a sensitive enzyme-linked immunosorbent assay and a [13C] urea breath test were used to investigate the prevalence ofH. pyloriinfection among 485 healthy asymptomatic volunteers between the ages of 15 and 80 residing in the Houston metropolitan area.H. pyloriinfection was present in 52%. The prevalence ofH. pyloriinfection increased rapidly with age at 1%/yr for the overall population. The frequency ofH. pyloriinfection was higher in blacks (70%) than whites (34%) (P< 0.001); this difference remained after adjustments were made for age, gender, educational level, income, and use of tobacco or alcohol.H. pyloriinfection was independent of gender but was closely correlated with socioeconomic class. There were significant inverse correlations between age-adjusted frequency ofH. pyloriinfection and income and between educational level andH. pyloriinfection. There was no association betweenH. pyloriinfection and consumption of alcohol or nonsteroidal antiinflammatory drug use or smoking. Having pets was associated with a lower frequency ofH. pyloriinfection, but this was highly associated with higher socioeconomic status. The mode(s) of transmission ofH. pyloriis unknown, but the social patterns ofH. pyloriinfection are consistent with fecal-oral transmission as one important pathway. Socioeconomic factors seem to determine the age of acquisition.