Magnetic micelles as a potential platform for dual targeted drug delivery in cancer therapy
Magnetic micelles as a potential platform for dual targeted drug delivery in cancer therapy
复制标题
磁性胶束作为癌症治疗中双靶向药物递送的潜在平台
DOI：
10.1016/j.ijpharm.2012.03.001
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发表时间：
2012-06-15
影响因子：
5.8
通讯作者：
Zhou, Shaobing
中科院分区：
文献类型：
--
作者：
Huang, Chi;Tang, Zhaomin;Zhou, Shaobing
磁性纳米胶束作为一种潜在的叶酸介导和磁导向双重靶向给药平台，被开发用于提高药物递送到肿瘤部位的效率和准确性。以超顺磁性氧化铁纳米粒（SPIONs）、生物相容性良好的Pluronic F127和聚乳酸（F127-PLA）共聚物为载体，通过简单的化学偶联法将肿瘤靶向配体叶酸（FA）化学偶联，制备了磁性纳米载体。以盐酸多柔比星（DOX center dot HCl）为模型抗癌药物，研究了在0.1T的磁场作用下，药物的体外释放及对肿瘤细胞的体内外抗增殖作用。Alcohol blue检测结果表明，磁性纳米胶束具有明显的细胞靶向性。此外，这种智能系统能够使叶酸受体介导的摄取进入肿瘤细胞，对MF表现出强烈的反应性。在携带VX 2肿瘤的雄性新西兰白色兔中进行的初步体内肿瘤模型研究表明，通过应用MF，纳米胶束可以更有效地被引导到肿瘤部位，并且进一步表现出对实体瘤的显著治疗效果。(c)2012爱思唯尔有限公司版权所有。
The magnetic nanomicelles as a potential platform for dual targeted (folate-mediated and magnetic-guided) drug delivery were developed to enhance the efficiency and veracity of drug delivering to tumor site. The magnetic nanocarriers were synthesized based on superparamagnetic iron oxide nanoparticles (SPIONs), biocompatible Pluronic F127 and poly(DL-lactic acid) (F127-PLA) copolymer chemically conjugated with tumor-targeting ligand-folic acid (FA) via a facile chemical conjugation method. Doxorubicin hydrochloride (DOX center dot HCl) was selected as a model anticancer drug to investigate the in vitro drug release and antiproliferative effect of tumor cells in vitro and in vivo in the presence or absence of an external magnetic filed (MF) with strength of 0.1T. The Alamar blue assay exhibited that these magnetic nanomicelles possessed remarkable cell-specific targeting in vitro. Additionally this smart system enabling folate receptor-mediated uptake into tumor cells, showed strong responsiveness to MF. The primary in vivo tumor model study, which was carried out in VX2 tumor-bearing male New Zealand white rabbits, demonstrated that the nanomicelles could be guided into tumor site more efficiently by application of MF, and further represented significant therapeutic efficiency to solid tumor. (c) 2012 Elsevier B.V. All rights reserved.