A novel method of expressing left ventricular mass relative to body size in children
A novel method of expressing left ventricular mass relative to body size in children
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DOI：
10.1161/circulationaha.107.741157
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发表时间：
2008-05-27
期刊：
影响因子：
37.8
通讯作者：
Colan, Steven D.
中科院分区：
文献类型：
--
作者：
Foster, Bethany J.;Mackie, Andrew S.;Colan, Steven D.
背景-儿童左心室肥厚（LVH）被广泛定义为左心室质量指数（LVMI，g/m（2.7））>第95百分位数。然而，LVMI随着幼儿身高的降低而增加;因此，第95百分位数LVMI将取决于参考人群的身高分布。本研究的目的是比较性能的一种新的方法，表示左心室质量相对于身体大小（百分位曲线）与LVMI的方法和结果左心室质量估计M型超声心动图在440名健康的非肥胖参考儿童（出生到21岁）和239名儿童的左心室肥厚的风险;计算所有儿童的LVMI。从参考人群中抽取了三个样本，每个样本有270名儿童，每个儿童具有不同的身高分布。测定每个参考样本的样本特异性第95百分位数LVMI。高危儿童根据每个样本特异性第95百分位数分为左心室肥厚或非左心室肥厚。采用科尔法和每个参考样本的数据构建了4条LV质量-身高百分位数曲线。根据这些曲线，为高危儿童分配一个左心室质量-身高百分位数，如果左心室质量-身高百分位数>第95百分位数，则将其重新分类为左心室肥厚。百分位数方法提供了一个稳定的估计比例的风险儿童LVH的参考组，而比例估计值变化显着时，LVMI方法used.Conclusions-LV质量的高度百分位数曲线是上级LVMI作为一种方法，正常化的LV质量，以身体大小的儿童。
Background-Left ventricular (LV) hypertrophy (LVH) in children is widely defined as a left ventricular mass index (LVMI, g/m(2.7)) > 95th percentile. However, LVMI increases with decreasing height in young children; thus, the 95th percentile LVMI will depend on the height distribution of the reference population. The objective of this study was to compare the performance of a novel method of expressing LV mass relative to body size (centile curves) with the LVMI method.Methods and Results-LV mass was estimated by M-mode echocardiography in 440 healthy nonobese reference children (birth to 21 years) and 239 children at risk for LVH; the LVMI was calculated for all children. Three samples of 270 children, each with different height distributions, were drawn from the reference population. A sample-specific 95th percentile LVMI was determined for each reference sample. At-risk children were classified as having LVH or not based on each sample-specific 95th percentile. Four LV mass-for-height centile curves were constructed with the Cole lambda-mu-sigma method and data from each reference sample. At-risk children were each assigned an LV mass-for-height percentile with these curves and were reclassified as having LVH if LV mass-for-height was > 95th percentile. The centile method provided a stable estimate of the proportion of at-risk children with LVH regardless of reference group, whereas proportion estimates varied significantly depending on the reference population when the LVMI method was used.Conclusions-LV mass-for-height centile curves are superior to LVMI as a method of normalizing LV mass to body size in children.