Drugs for Neglected Diseases initiative model of drug development for neglected diseases: current status and future challenges
Drugs for Neglected Diseases initiative model of drug development for neglected diseases: current status and future challenges
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DOI：
10.4155/fmc.11.102
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发表时间：
2011-09-01
影响因子：
4.2
通讯作者：
Chang, Shing
中科院分区：
文献类型：
--
作者：
Ioset, Jean-Robert;Chang, Shing
The Drugs for Neglected Diseases initiative (DNDi) is a patients' needs-driven organization committed to the development of new treatments for neglected diseases. Created in 2003, DNDi has delivered four improved treatments for malaria, sleeping sickness and visceral leishmaniasis. A main DNDi challenge is to build a solid R&D portfolio for neglected diseases and to deliver preclinical candidates in a timely manner using an original model based on partnership. To address this challenge DNDi has remodeled its discovery activities from a project-based academic-bound network to a fully integrated process-oriented platform in close collaboration with pharmaceutical companies. This discovery platform relies on dedicated screening capacity and lead-optimization consortia supported by a pragmatic, structured and pharmaceutical-focused compound sourcing strategy.
