Low intake of digestible carbohydrates ameliorates duodenal absorption of carbohydrates in mice with glucose metabolism disorders induced by artificial sweeteners
Low intake of digestible carbohydrates ameliorates duodenal absorption of carbohydrates in mice with glucose metabolism disorders induced by artificial sweeteners
复制标题
低摄入可消化碳水化合物可改善人工甜味剂诱导的葡萄糖代谢紊乱小鼠十二指肠对碳水化合物的吸收
DOI：
10.1002/jsfa.9727
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发表时间：
2019-08-30
影响因子：
4.1
通讯作者：
Deng, Shaoping
中科院分区：
文献类型：
--
作者：
Shi, Qing;Cai, Lei;Deng, Shaoping
据报道，长期食用人工甜味剂会诱发葡萄糖耐受不良，肠道菌群似乎是一个重要的目标。虽然人工甜味剂对能量平衡的影响仍存在争议，但本研究旨在评估低可消化碳水化合物（LDC）饮食对小鼠血浆葡萄糖、血浆空腹胰岛素、甜味受体、葡萄糖转运蛋白、碳水化合物吸收以及乙酰糖苷钾（AK）或糖精（SAC）消耗的保护作用。结果人工甜味剂连续12周诱导小鼠糖代谢紊乱；最后6周给小鼠喂食低脂饮食。实验组采用与正常饮食组能量相同的低脂饮食。长期使用人工甜味剂会导致代谢功能障碍，其特征是血糖、胰岛素抵抗、甜味受体、葡萄糖转运蛋白和碳水化合物吸收显著增加。用最不发达国家饮食治疗可以积极调节这些改变的参数，表明最不发达国家饮食对与人工甜味剂相关的有害变化的总体有益影响。结论在饮食中减少可消化碳水化合物可显著减少碳水化合物的吸收，改善饮食因素引起的糖代谢紊乱。这些影响可能是由于减少饲料中可消化碳水化合物的数量可以减少暴露于人工甜味剂诱导的肠道甜味受体的数量。(c) 2019年化学工业学会
Background Long-term artificial sweetener consumption has been reported to induce glucose intolerance, and the intestinal microbiota seems as an important target. While the impacts of artificial sweeteners on energy balance remain controversial, this work aimed to evaluate the protective effects in mice of a low digestible carbohydrate (LDC) diet on plasma glucose, plasma fasting insulin, sweet taste receptors, glucose transporters, and absorption of carbohydrates, together with consumption of acesulfame potassium (AK) or saccharin (SAC). Results Artificial sweetener was administered to mice for 12 weeks to induce glucose metabolism disorders; mice were treated with an LDC diet for the final 6 weeks. The experimental groups were treated with an LDC diet that had the same energy as the normal-diet group. Prolonged administration of artificial sweeteners led to metabolic dysfunction, characterized by significantly increased plasma glucose, insulin resistance, sweet taste receptors, glucose transporters, and absorption of carbohydrates. Treatment with an LDC diet positively modulated these altered parameters, suggesting overall beneficial effects of an LDC diet on detrimental changes associated with artificial sweeteners. Conclusions Reducing digestible carbohydrates in the diet can significantly reduce the absorption of carbohydrates and improve glucose metabolism disorders caused by dietary factors. These effects may be due to the fact that reducing the amount of digestible carbohydrates in the feed can reduce the number of intestinal sweet receptors induced by exposure to artificial sweeteners. (c) 2019 Society of Chemical Industry