Identification of evidence-based interventions for promoting HIV medication adherence: findings from a systematic review of U.S.-based studies, 1996-2011.
Identification of evidence-based interventions for promoting HIV medication adherence: findings from a systematic review of U.S.-based studies, 1996-2011.
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DOI：
10.1007/s10461-013-0594-x
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发表时间：
2014-04
影响因子：
4.4
通讯作者：
HIV/AIDS Prevention Research Synthesis (PRS) Team
中科院分区：
文献类型：
--
作者：
Charania MR;Marshall KJ;Lyles CM;Crepaz N;Kay LS;Koenig LJ;Weidle PJ;Purcell DW;HIV/AIDS Prevention Research Synthesis (PRS) Team
进行了一项系统评价，以确定基于证据的干预措施（EBI），以增加艾滋病毒药物治疗依从性行为或降低艾滋病毒载量的人与艾滋病毒感染者（PLWH）。我们对电子数据库进行了自动搜索（即，MEDLINE、EMBASE、PsycINFO、CINAHL）和人工检索期刊、参考文献列表和列表服务器。干预措施有资格接受审查，如果他们是美国-基于，发表于1996年至2011年，旨在改善艾滋病毒感染者的药物依从性行为，使用对照组评估干预措施，并报告依从性行为或艾滋病毒载量的结果数据。对每种干预措施的研究设计、实施、分析和结果的质量进行了评价。在65项合格的干预措施中，10项是EBI。其余55项干预措施未能达到有效性标准，主要是由于无效结果、样本量小或保留率低。研究的差距和未来的发展方向进行了讨论。
A systematic review was conducted to identify evidence-based interventions (EBIs) for increasing HIV medication adherence behavior or decreasing HIV viral load among persons living with HIV (PLWH). We conducted automated searches of electronic databases (i.e., MEDLINE, EMBASE, PsycINFO, CINAHL) and manual searches of journals, reference lists, and listservs. Interventions were eligible for the review if they were U.S.-based, published between 1996 and 2011, intended to improve HIV medication adherence behaviors of PLWH, evaluated the intervention using a comparison group, and reported outcome data on adherence behaviors or HIV viral load. Each intervention was evaluated on the quality of study design, implementation, analysis, and strength of findings. Of the 65 eligible interventions, 10 are EBIs. The remaining 55 interventions failed to meet the efficacy criteria primarily due to null findings, small sample sizes, or low retention rates. Research gaps and future directions for development of adherence EBIs are discussed.