DRD1 and DRD2 Genotypes Modulate Processing Modes of Goal Activation Processes during Action Cascading
DRD1 and DRD2 Genotypes Modulate Processing Modes of Goal Activation Processes during Action Cascading
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DOI：
10.1523/jneurosci.5140-13.2014
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发表时间：
2014-04
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影响因子：
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通讯作者：
A. Stock;L. Arning;J. Epplen;C. Beste
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作者：
A. Stock;L. Arning;J. Epplen;C. Beste
多巴胺在动作选择中起着重要的作用，但人们对不同多巴胺受体系统对级联反应中发生的子过程的影响知之甚少。由于动作选择和级联可以以串行方式或并行方式完成，我们研究了DRD 1（rs 4531）和DRD 2（rs6277）受体多态性对这一维度的潜在影响。我们收集了来自健康人类受试者（n = 162）的行为和神经生理数据，并应用数学约束来量化他们在串行-并行连续体上的动作选择策略。行为结果显示，在纯合子DRD 1 G等位基因携带者中，更连续和更有效的动作级联策略，假定其具有比A等位基因携带者更高的D1受体效率。在纯合子DRD 2 T等位基因携带者组中，D2受体的纹状体密度高于C等位基因携带者，我们发现了一种效率较低且更平行的作用级联策略。这些发现表明，在同一样本中，更高的D1效率似乎会将动作级联策略转向更串行的处理模式，而D2受体似乎会通过诱导更并行的处理模式来促进相反方向的转变。此外，神经生理学分析表明，观察到的差异不是基于注意力的差异或基本抑制。相反，连接刺激处理和反应执行的过程似乎区分了更多的串行和更多的并行处理组。
Dopamine plays an important role in action selection, but little is known about the influence of different dopamine receptor systems on the subprocesses occurring during the cascading of actions. Because action selection and cascading can be accomplished in a serial manner or a parallel manner, we investigated the potential effects of DRD1 (rs4531) and DRD2 (rs6277) receptor polymorphisms on this dimension. We gathered behavioral and neurophysiological data from healthy human subjects (n = 162) and applied mathematical constraints to quantify their action selection strategy on a serial-parallel continuum. The behavioral results show a more serial and more effective action cascading strategy in homozygous DRD1 G allele carriers, who are assumed to have a higher D1 receptor efficiency than carriers of the A allele. In the group of homozygous DRD2 T-allele carriers, who have a higher striatal density of D2 receptors than C-allele carriers, we found a less effective and more parallel action cascading strategy. These findings suggest that, within the same sample, a higher D1 efficiency seems to shift the action cascading strategy toward a more serial processing mode, whereas the D2 receptors seem to promote a shift in the opposite direction by inducing a more parallel processing mode. Furthermore, the neurophysiological analysis shows that the observed differences are not based on attentional differences or basic inhibition. Instead, processes linking stimulus processing and response execution seem to differentiate between more serial and more parallel processing groups.