Formation of Hypoxanthine Tetrad by Reaction with Sodium Chloride: From Planar to Stereo
Formation of Hypoxanthine Tetrad by Reaction with Sodium Chloride: From Planar to Stereo
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与氯化钠反应形成次黄嘌呤四分体：从平面到立体
DOI：
10.1002/anie.201808613
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发表时间：
2018-12-03
影响因子：
16.6
通讯作者：
Yu, Miao
中科院分区：
文献类型：
--
作者：
Chen, Chong;Ding, Pengcheng;Yu, Miao
通过在Au（111）上与NaCl反应，在实际空间的原子尺度上证明了次黄嘌呤（HX）四体的形成。这些结果直接证明了嘌呤四聚体可以在平面和非平面构型中形成，离子键在四聚体的形成和从平面到立体的转化中起着至关重要的作用，为构建人工DNA/RNA四聚体提供了更深入的见解。此外，倾斜的HXs和Na在非平面相中都表现出与衬底的强电荷转移。这项工作所获得的见解也为调整金属有机界面的静电性质和设计表面上的立体纳米结构开辟了新的途径。
By reacting with NaCl on Au(111), the formation of hypoxanthine (HX) tetrads is demonstrated at the atomic scale in real space. These results directly demonstrate that alternative purine tetrads can be formed in both planar and non-planar configuration, and that ionic bonding plays a crucial role for the formation and planar-to-stereo transformation of the tetrads, providing deeper insight for constructing artificial DNA/RNA quadruplexes. Moreover, both the tilted HXs and Na show strong charge transfer with the substrate in the non-planar phase. The insights gained by this work also open up new routes to tune the electrostatic nature of metal-organic interfaces and design stereo-nanostructures on surfaces.