Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma
Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma
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Stat3和Notch1的表达与头颈鳞癌顺铂耐药相关
DOI：
10.3892/or_00000683
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发表时间：
2010-03-01
期刊：
影响因子：
4.2
通讯作者：
Fu, Li
中科院分区：
文献类型：
--
作者：
Gu, Feng;Ma, Yongjie;Fu, Li
顺铂是治疗头颈部鳞状细胞癌最重要的化疗药物，但头颈部鳞状细胞癌的顺铂耐药仍是临床上的一个严重问题。患者化疗失败的原因尚不清楚。我们检测了25例HNSCC患者，均通过CD-DST（胶原凝胶液滴包埋培养-药物敏感性）方法检测顺铂敏感性和Stat 3和Notch 1的表达。Stat 3和Notch 1的高表达分别与顺铂耐药密切相关（P=0.014，P=0.000）。此外，抑制Stat 3或Notch信号通路可降低HNSCC对顺铂的耐药性。我们的研究结果提供了第一个证据，即高Stat 3和Notch 1表达与HNSCC患者的顺铂耐药相关，支持了Stat 3和Notch 1通过其串扰共激活诱导HNSCC对化疗应答的重编程生存途径的假设。
Cisplatin is the most important chemotherapeutic agent involved in treatment of head and neck squamous cell carcinoma (HNSCC), but cisplatin resistance in HNSCC is still a serious problem in clinic. The reasons why patients fail chemotherapy are unclear. We examined 25 HNSCC patients who were all tested for cisplatin sensitivity by CD-DST (collagen gel droplet embedded culture-drug Sensitivity) method and expression of Stat3 and Notch1. We found that high expression levels of Stat3 and Notch1 were closely associated with cisplatin resistance respectively (P=0.014, P=0.000). fit addition, cisplatin resistance of HNSCC was decreased after inhibition of Stat3 or Notch signaling in vitro. Our results provide first evidence that both high Stat3 and Notch1 expression are associated with cisplatin resistance in HNSCC patients, Supporting the hypothesis that coactivation of Stat3 and Notch1 by their crosstalk induces the reprogrammed survival pathways in HNSCC responding to chemotherapy.