Past and future episodic detail retrieval is reduced among clinically normal older adults at higher genetic risk for late-onset Alzheimer's disease.
Past and future episodic detail retrieval is reduced among clinically normal older adults at higher genetic risk for late-onset Alzheimer's disease.
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对于晚发性阿尔茨海默病遗传风险较高、临床正常的老年人来说，过去和未来的情景细节检索会减少。
DOI：
10.1037/neu0000866
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发表时间：
2023
期刊：
影响因子：
2.4
通讯作者：
Grilli,MatthewD
中科院分区：
文献类型：
--
作者：
Acevedo-Molina,MónicaC;Thayer,SeanC;Horn,Kiley;Nkulu,Hanna;Ryan,Lee;Andrews-Hanna,JessicaR;Grilli,MatthewD
记忆和想象的个人事件，是丰富的情节（即特定事件）的细节是妥协的老年人谁有轻度认知障碍，一个已知的风险因素阿尔茨海默氏症痴呆症。不太清楚的是，在轻度临床衰退可检测到之前，较低的情节细节生成是否与阿尔茨海默病痴呆的较高风险相关。方法我们比较了阿尔茨海默病相关载脂蛋白E e4等位基因临床正常老年人携带者过去和未来的自传体思维结果APOE 4携带者在回忆过去事件时，对情节细节的记忆能力明显降低（d = 0. 05），而非APOE 4携带者（n= 43）的记忆能力明显降低（d= 0. 05）。47)想象未来的事情（D）46），但不为nonepisodic details.ConclusionsThese研究结果表明，APOE4与选择性减少情节的细节在过去和未来的自传体思维临床正常的老年人。因此，减少情节细节生成可能是阿尔茨海默病痴呆风险较高的早期认知关联。
ObjectiveRemembering and imagining personal events that are rich in episodic (ie, event-specific) detail is compromised in older adults who have mild cognitive impairment, a known risk factor for Alzheimer’s disease dementia. Less clear is whether lower episodic detail generation is associated with higher risk for Alzheimer’s disease dementia before mild clinical decline is detectable.MethodWe compared past and future autobiographical thinking in clinically normal older adult carriers of the Alzheimer’s disease-associated apolipoprotein E e4 allele (APOE4; n= 39) to demographically and neuropsychologically similar non-APOE4 carriers (n= 43).ResultsAPOE4 carriers showed a significant reduction for episodic details when remembering past events (d=. 47) and imagining future events (d=. 46), but not for nonepisodic details.ConclusionsThese findings suggest that APOE4 is associated with a selective reduction of episodic detail during past and future autobiographical thinking among clinically normal older adults. Reduced episodic detail generation, therefore, may be an early cognitive associate of higher risk for Alzheimer’s disease dementia.