Temporary inactivation of the dorsal hippocampus induces a transient impairment in retrieval of aversive memory
Temporary inactivation of the dorsal hippocampus induces a transient impairment in retrieval of aversive memory
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DOI：
10.1016/j.bbr.2007.02.031
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发表时间：
2007-06-18
影响因子：
2.7
通讯作者：
Roesler, Rafael
中科院分区：
文献类型：
--
作者：
Amaral, Olavo B.;Luft, Tatiana;Roesler, Rafael
再巩固假说（reconsolidation hypothesis）是近年来记忆研究中最具争议的话题之一，该假说预测，巩固的记忆在重新激活后会变得不稳定并对遗忘剂敏感。对这一假说的主要批评之一是，一些研究表明，“再巩固阻滞”的影响是短暂的。在这里，我们表明，蝇蕈醇失活的背海马记忆再激活产生可逆性损害的降压抑制性回避记忆大鼠。此外，我们表明，这种效果的逆转是依赖于时间的推移，而不是重复测试。研究结果的影响，解释的现象，短暂的检索损伤诱导后再激活药理学干预记忆系统进行了讨论。(c)2007 Elsevier B.V.保留所有权利。
The reconsolidation hypothesis, which predicts that consolidated memories become labile and sensitive to amnestic agents upon reactivation, has been one of the most debated topics in memory research over recent years. One of the main criticisms to this hypothesis is the fact that some studies have shown the effects of "reconsolidation blockade" to be transient. Here we show that muscimol inactivation of the dorsal hippocampus following memory reactivation produces a reversible impairment of step-down inhibitory avoidance memory in rats. Moreover, we show that the reversal of this effect is dependent on the passage of time, and not on repeated testing. The implications of the findings to the interpretation of the phenomenon of transient retrieval impairment induced by post-reactivation pharmacological interventions on memory systems are discussed. (c) 2007 Elsevier B.V. All rights reserved.